Associated factors of umbilical cord blood collection quality |
| |
| Authors: | Lionel Faivre Hélène Boucher Thomas Domet André Desproges Olivier Sibony Marina Bechard Valérie Vanneaux Jérôme Larghero Audrey Cras |
| |
| Affiliation: | 1. AP‐HP, H?pital Saint‐Louis, Unité de Thérapie CellulaireLF and CC contributed equally to this work.;2. AP‐HP, H?pital Saint‐Louis, Unité de Thérapie Cellulaire;3. Université Paris Descartes, Sorbonne Paris Cité;4. Université Paris Diderot, Sorbonne Paris Cité;5. Institut Hospitalier Franco‐Britannique, Levallois‐Perret;6. Inserm, UMR_S1160, Centre d'Investigation Clinique en Biothérapies;7. Inserm UMR_S1140, Faculté de Pharmacie, Paris, France |
| |
| Abstract: | After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection. |
| |
| Keywords: | |
|
|
