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| 慢性粒单核细胞白血病的临床特点和预后分析 | |
| 引用本文： | 黄济舟,陈燕. 慢性粒单核细胞白血病的临床特点和预后分析[J]. 临床血液学杂志, 2010, 0(3) |
| 作者姓名： | 黄济舟 陈燕 |
| 作者单位： | 华中科技大学同济医学院附属协和医院血液病研究所; |
| 摘 要： | 目的:本研究探讨慢性粒单核细胞型白血病(CMML)的临床特点及影响其预后的相关因素,评估IPSS、WPSS及MDAPS3个积分系统在CMML预后中的应用意义。方法:选取我院2003年5月-2009年7月CMML病例18例,选取同期急性单核细胞白血病(AML-M5)58例作为对照。结果:CMML伴有明显的多系病态造血。干细胞相关抗原CD34、CD117的表达较低,HLA-DR、CD117、CD14抗原表达均低于AML-M5(P<0.05),CD11b抗原表达高于AML-M5(P<0.05)。结论:WPSS积分系统对CMML的预后评估较为理想;CMML时干细胞相关抗原的表达均较低;CD11b高表达可能与CMML的预后不良有关;常规化疗对CMML的治疗效果不佳,造血干细胞移植是目前惟一有可能治愈CMML的方法。 |
| 关 键 词： | 白血病 粒单核细胞性 慢性 WPSS积分 IPSS积分 MDAPS积分 预后 |
Clinical characterization and prognostic analysis of chronic myelomonocytic leukemia |
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| HUANG Jizhou CHEN Yan. Clinical characterization and prognostic analysis of chronic myelomonocytic leukemia[J]. Journal of Clinical Hematology, 2010, 0(3) | |
| Authors: | HUANG Jizhou CHEN Yan |
| Affiliation: | Department of Hematology/a>;Union Hospital/a>;Tongji Medical College/a>;Huazhong University of Science and Technology/a>;Wuhan/a>;430022/a>;China |
| Abstract: | Objective:The aims of this study were to investigate the clinical characteristics and influencing factors of prognosis of CMML,and assess the prognostic significance of WHO-based Prognostic Scoring System (WPSS),International Prognostic Scoring System (IPSS),and M.D. Anderson Prognostic Score (MDAPS).Method:Eighteen cases with CMML diagnosed according to the criteria of WHO classification were retrospectively analyzed,58 cases with AML-M5 of the same time period were taken as control. All of them were follo... |
| Keywords: | leukemia myelomonocytic chronic IPSS WPSS MDAPS prognosis |
| 本文献已被 CNKI 等数据库收录！ | |