地肤子化学成分的研究

目的对地肤子乙醇提取物化学成分进行分离和结构鉴定。方法通过大孔树脂、硅胶和凝胶柱色谱分离;利用多种波谱技术并结合文献对照鉴定化合物结构。结果分离鉴定了16个化合物,分别为正十八烷酸(1)、β-谷甾醇(2)、齐墩果酸(3)、胡萝卜苷(4)、5,7,4’-三羟基-6,3’-二甲氧基黄酮(5)、5,7,4’–三羟基-6-甲氧基黄酮(6)、异鼠李素(7)、槲皮素(8)、异鼠李素-3-O-β-D-吡喃葡萄糖苷(9)、芦丁(10)、齐墩果酸-3-O-β-D-吡喃葡萄糖醛酸苷(11)、齐墩果酸-3-O-β-D-吡喃木糖(1→3)-β-D-吡喃葡萄糖醛酸甲酯苷(12)、齐墩果酸-3-O-β-D-吡喃木糖(1→3)-β-D-吡喃葡萄糖醛酸苷(13)、3-O-β-D-吡喃葡萄糖醛酸-齐墩果酸-28-O-β-D-吡喃葡萄糖酯苷(14)、3-O-β-D-吡喃木糖(1→3)-β-D-吡喃葡萄糖醛酸-齐墩果酸-28-O-β-D-吡喃葡萄糖酯苷(15)、3-O-{[β-D-吡喃葡萄糖(1→2)]-[β-D-吡喃木糖(1→3)]}-β-D-吡喃葡萄糖醛酸-齐墩果酸-28-O-β-D-吡喃葡萄糖酯苷(16)。结论化合物5～10为首次从地肤子中分离得到。

Study on Chemical Constituents of Kochia scoparia

OBJECTIVE To study the constituents in the fruits of Kochia scoparia.METHODS Various column chromatographic techniques were used to isolate the constituents,and their structures were identified by ESI-MS,NMR spectral data and by comparison spectra with literature data.RESULTS Sixteen compounds were isolated and elucidated as stearic acid(1),β-sitosterol(2),oleanolic acid(3),daucosterol(4),5,7,4′-trihydroxy-6,3′-dimethoxyflavone(5),5,7,4′-trihydroxy-6-methoxyflavone(6),isorhamnetin(7),quercetin(8),isorhamnetin-3-O-β-D-glucopyranoside(9),rutin(10),oleanolic acid-3-O-β-D-glucuronopyranoside(11),oleanolic acid-3-O-β-D-xylopyranosyl(1→3)-β-D-(6-O-methyl)-glucuronopyranoside(12),oleanolic acid-3-O-β-D-xylopyranosyl(1→3)-β-D-glucuronopyranoside(13),3-O-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyranoside(14),3-O-β-D-xylopyranosyl(1→3)-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyranoside(15),3-O-{[β-D-β-D-glucopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-)-β-D-glucuronopyranosyl oleanolic acid-28-O-β-D-glucopyranoside(16).CONCLUSION Compounds 5-10 were isolated from Kochia scoparia.for the first time.