首页 | 本学科首页   官方微博 | 高级检索  
     

肠道屏障功能在非酒精性脂肪性肝病发病机制中的作用
引用本文:戴鑫,吕宗舜. 肠道屏障功能在非酒精性脂肪性肝病发病机制中的作用[J]. 世界华人消化杂志, 2012, 0(8): 656-661
作者姓名:戴鑫  吕宗舜
作者单位:天津医科大学总医院
摘    要:
非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种常见的慢性肝脏疾病,且发病率有逐年上升的趋势.关于其发病的具体机制的研究从未停止.自马歇尔(Marshall)于1998年正式提出了"肠-肝轴"的概念,肠道屏障功能在NAFLD发病机制中的作用逐渐成为关注的重点.肠道屏障功能的4大方面机械屏障、化学屏障、生物屏障、免疫屏障相互密切联系,并且与NAFLD之间的关系也密不可分.本文对近年来关于肠道屏障功能与NAFLD的发生和发展的相关性研究结果进行综述,旨在探讨在NAFLD的发病机制中肠道屏障功能所起到的作用.

关 键 词:非酒精性脂肪性肝病  肠道屏障功能  肝肠轴

Role of gut barrier function in the pathogenesis of nonalcoholic fatty liver disease
Xin Dai, Zong-Shun Lv. Role of gut barrier function in the pathogenesis of nonalcoholic fatty liver disease[J]. World Chinese Journal of Digestology, 2012, 0(8): 656-661
Authors:Xin Dai   Zong-Shun Lv
Affiliation:, Department of Gastroenterology, General Hospital of Tianjin Medical University, Tianjin 300052, China
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, and its incidence is increasing year by year. Many efforts have been made to investigate the pathogenesis of this disease. Since 1998 when Marshall proposed the conception of "gut-liver axis", more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD. The four aspects of gut barrier function, including physical, chemical, biological and immunological barriers are interrelated closely and related to NAFLD. In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the occurrence and development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.
Keywords:Nonalcoholic fatty liver disease  Gut- barrier function  Gut-liver axis
本文献已被 CNKI 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号