基于循证医学的慢性丙型肝炎患者病毒基因分型与中医证候之间的关系探讨

目的：探讨慢性丙型肝炎（ CHC）中医证候与病毒基因型的关系。方法：采用问卷调查与实验室检测相结合的形式，统计患者的中医症候体征规律，丙型肝炎病毒（ HCV）基因分型采用基因测序法检测，采用Logistic回归进行相关性分析。结果：我国CHC患者病毒基因型以1型为主，中医证型以正虚邪恋型为主，病毒基因型和中医证型间不存在相关性，临床症状胁肋隐痛与HCV基因型存在相关性，且症状越重，病毒基因1、6型出现的机率越大。结论： HCV患者临床宏观症状与微观指标之间可能存在某些联系，该结果将为进一步研究CHC的宏观与微观之间的联系提供流行病学依据。

Relationship between chronic hepatitis C virus genotype and traditional Chi-nese medicine syndrome based on evidence-based medicine

Objective： To evaluate the relationship between chronic hepatitis C virus genotype and traditional Chinese med-icine syndrome.Methods： This study adopted the combining form of the questionnaire investigation and laboratory tests, record-ing the patient′s symptoms and signs of traditional Chinese medicine and so on, gene sequencing method was applied to detect chronic hepatitis C virus genotype, and all the data were analyzed with Logistic regression analysis.Results： Chronic hepatitis C virus genotype in China was dominanted with type 1 and type of syndrome was similar with deficient vital Qi with residuary pathogen.There was no correlation between virus genotype and TCM syndrome type.However, there was an association between indistinct pain over hypochondrium and hepatitis C virus genotype, and virus genotype 1, 6 occurrence probability increases with the symptom aggravating.Conclusion： There may be some contact between the clinical symptoms of macroscopic and microcos-mic indexes in patients with chronic hepatitis C, and it will provide basis for further epidemiological studies of chronic hepatitis C between the macroscopic symptom and the microcosmic index.