Combination of ABO blood group incompatibility and glucose-6-phosphate dehydrogenase deficiency: effect on hemolysis and neonatal hyperbilirubinemia |
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| Authors: | M Kaplan HJ Vreman C Hammerman C Leiter B Rudensky MG MacDonald DK Stevenson |
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| Affiliation: | Department of Neonatology, Childrens'National Medical Center, George Washington University School of Medicine and Health Sciences, Washington DC, USA;Hematology Laboratory, Childrens'National Medical Center, George Washington University School of Medicine and Health Sciences, Washington DC, USA;Shaare Zedek Medical Center, Hebrew University, Hadassah Medical School, Jerusalem, Israel, Childrens'National Medical Center, George Washington University School of Medicine and Health Sciences, Washington DC, USA;Department of Pediatrics, Childrens'National Medical Center, George Washington University School of Medicine and Health Sciences, Washington DC, USA;Stanford University Medical Center, Stanford, CA, and Division of Neonatology, Childrens'National Medical Center, George Washington University School of Medicine and Health Sciences, Washington DC, USA |
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| Abstract: | The incidence (%) of hyperbilirubinemia (serum bilirubin ≥257 μmol/l) was similar in neonates with a combination of ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency (37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 ± 0.32%, 0.82 ± 0.29%, 0.76 ± 0.18%, respectively, ns), but correlated with bilirubin only in those with ABO incompatibility alone. ABO-incompatible/G-6-PD-deficient neonates, compared with those with either condition alone, are not at increased risk for hemolysis or hyperbilirubinemia. |
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| Keywords: | ABO blood group incompatibility carboxyhemoglobin glucose-6-phosphate dehydrogenase deficiency hyperbilirubinemia neonatal hemolysis Sephardic Jews |
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