干燥法长期保存角膜片板层治疗性角膜移植1267例临床研究

目的：评价干燥脱水法长期保存角膜片在板层治疗性角膜移植术中的效果。方法：保存角膜片选自我院眼库干燥保存符合临床标准、复水透明的完整角膜片，临床病例选自我院角膜病组1976年8月—1999年12月期间行板层治疗性角膜移植患者1267例，从手术前后视力比较、原发病灶控制、植片存活情况进行临床效果综合分析。结果：保存角膜片复水透明合格率为94．9％，临床治愈率：感染性角膜溃疡／穿孔88．8％，血管属性全角膜白斑98．3％，化学及热烧伤(穿孔，睑球角粘连等)92．1％，圆锥角膜及急性圆锥角膜99.5％，角膜变性(边缘性及前基质层)99.0％，其他88．9％，平均总治愈率：93．5％。结论：1．对各种严重的角膜感染、药物治疗无法控制的病人，治疗性角膜移植术是唯一有效的方法。2．采用无水氯化钙——硅胶干燥脱水长期保存的供体角膜能为临床随时提供角膜材料，是一项简单易行、便于推广应用的成功率很高的保存方法。眼科学报2003；19：110-113

The Clinical Study of 1 267 Cases Therapeutic Keratoplasty Using Donor Corneal Grafts in Long-time Preservation with Dehydrated

Purpose:To evaluate its effects of 1 267 cases therapeutic keratoplasty using donor corneal grafts in long-time preservation with dehydrated. Methods:The long-time preservated donor corneal grafts came from Xi'an Eye Bank, they accorded with the clinical demands. To select 1 267 cases therapeutic keratoplasty in August 1976 to December 1999,and make an analysis of preoperation and post-operation visual contrast, original focus controlling, donor corneal grafts reviviscence. Result:The transparent rate of donor corneal grafts after presevation was 94.9%, the clinical cure rate: Infective corneal ulcer/perforation 88.8% , pannus totalis and corneal opacity 98.3% , chemical burn and heat burn (perforation corneoblepharon) 92.1%,keratoconus and acute keratoconus 99.5%, corneal degeneration (marginal shallow of stroma) 99.0%,other cases 88.9%, mean all effective rate 93.5%. Conclusion: 1.For the treatment of serious corneal infection,and cases which poorly respond to medicine, therapeutic keratoplasty may be the only effective method. 2.Longtime corneal dehydration in water-free calcium chloride-silica gel may provide clinical supply of corneal materials whenever necessary, so it is an easy and simple, highly applicable method. Eye Science 2003;19:110-113.