小剂量多西环素治疗慢性牙周炎的疗效和对基质金属蛋白酶8的影响

Objective To investigate the effect of low-dose doxycycline(LDD)on the level of gingival crevicular fluid(GCF) matrix metalloproteinases-8 ( MMP-8 ) in chronic periodontitis. Methods Twenty patients with chronic periodontitis were selected and randomly divided into two groups( n = 10 in each group). After scaling and root planning( SRP), the SRP + LDD group received LDD for 3 months, whereas the SRP + P group received placebo 3 months. The patients were evaluated every 3 months during the 12-month study period. The plaque index( PLI),gingival index( GI), probing depth( PD), attachment loss(AL) and GCF samples were collected at each visit. The level of MMP-8 were detected and analyzed. Results Compared to baseline, the scores of PLI, GI, PD, AL and MM P-8 of the two groups showed statistically improvement during the 12-month study period (P ＜ 0.05 ). Compared to the SRP + P group, the SRP + LDD group showed statistically differences of GI, PD at 9,12-month visit. Conclusion Adjunctive SDD therapy can improve the clinical parameters and this clinical improvement is reflected by level of MMP-8 in chronic periodontitis after the therapy.

Effect of low-dose doxycycline on the level of gingival crevicnlar fluid matrix metalloproteinases-8 in chronic periodontitis