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益气活血法对AA大鼠滑膜细胞凋亡及血清细胞因子的影响
引用本文:陈利锋,潘立文,赵映前. 益气活血法对AA大鼠滑膜细胞凋亡及血清细胞因子的影响[J]. 湖北中医药大学学报, 2010, 12(6)
作者姓名:陈利锋  潘立文  赵映前
作者单位:湖北中医药大学,湖北,武汉,430065;湖北省中医院,湖北,武汉,430061
基金项目:广州军区武汉总医院课题(201006)
摘    要:目的选用黄芪注射液与川芎嗪注射液配伍,观察益气活血法对佐剂性关节炎(AA)大鼠滑膜细胞凋亡及血清细胞因子的影响。方法建立AA大鼠模型,设正常对照组、模型对照组、黄芪组、川芎嗪组、黄芪与川芎嗪配伍组和甲氨喋呤组进行对比观察,用药3周后检测各组大鼠足跖肿胀程度,滑膜细胞凋亡及血清细胞因子浓度。结果黄芪与川芎嗪配伍组能显著抑制注射足跖肿胀程度(P0.05),显著提高滑膜细胞的凋亡率(P0.01),并降低大鼠血清中IL-1、TNF-α、IL-6的水平(均P0.01),上调IL-4的浓度(P0.01),与甲氨喋呤组效果相当,甚至优于甲氨喋呤组。结论益气活血法可能通过促进AA大鼠滑膜细胞的凋亡,抑制某些炎性因子的释放,起到治疗类风湿性关节炎(RA)的作用。

关 键 词:益气活血法  佐剂性关节炎  细胞凋亡  细胞因子

The influence of the therapy of Tonifying Qi and Eliminating Blood Stasis on Synovial Cell Apoptosis and Serum Cytokines in Adjuvant Arthritis Rats
CHEN Lifeng,PAN Liwen,ZHAO Yingqian. The influence of the therapy of Tonifying Qi and Eliminating Blood Stasis on Synovial Cell Apoptosis and Serum Cytokines in Adjuvant Arthritis Rats[J]. Journal of Hubei University of Chinese Medicine, 2010, 12(6)
Authors:CHEN Lifeng  PAN Liwen  ZHAO Yingqian
Affiliation:CHEN Lifeng1,PAN Liwen2,ZHAO Yingqian2(1.Grade 2009 PhD student,Hubei University of Chinese Medicine,Wuhan 430075,Hubei,2.Hubei Hospital of Traditional Chinese Medicine,Wuhan 430061,Hubei)
Abstract:Objective To observe the effect of Astragalus root and chuanxiongzine injection used in combination(called combination treatment group) on synovial cell apoptosis and serum cytokines in Adjuvant Arthritis(AA) rats to explore the mechanism of the therapy of tonifying qi and eliminating blood stasis in treating AA.Methods AA rat model was established.The rats were randomly divided into six groups:normal,model,Astragalus root treatment,chuanxiongzine treatment,combination treatment and MTX treatment.The influe...
Keywords:the therapy of tonifying qi and eliminating blood stasis  Adjuvant Arthritis Rats  Cell Apoptosis  Cytokines  
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