| EV71的流行病学现状及研究进展 |
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| 引用本文： | 刘小乖,刘黎明. EV71的流行病学现状及研究进展[J]. 中国妇幼健康研究, 2012, 23(5): 681-684. DOI: 10.3969/j.issn.1673-5293.2012.05.049 |
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| 作者姓名： | 刘小乖 刘黎明 |
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| 作者单位： | 1.西安市交通大学医学院第一附属医院,陕西,西安,710061;西安市儿童医院感染科,陕西,西安,710061;2.西安市交通大学医学院第一附属医院,陕西,西安,710061 |
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| 摘 要： | 随着手足口病的广泛蔓延,世界各地对该疾病越来越关注.该病主要是由EV71感染引起.EV71具有嗜皮肤和嗜神经特性,临床上除了可以引起手足口病和疱疹性咽峡炎外,还可以引起严重的神经系统疾病,更有甚者出现死亡.在临床上主要表现为无菌性脑膜炎、脑干脑炎、神经源性肺水肿和脊髓灰质炎样的麻痹等多种神经系统疾病.减轻病人的症状,并找到有效的治疗方法是预防的关键,对EV71感染的发病机制、不同临床表现、病毒基因型及手足口病疫苗等方面有待进一步研究.
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| 关 键 词： | 手足口病 EV71病毒 流行病学 基因型 |
Epidemiological status and research progress of EV71 |
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| LIU Xiao-guai , LIU Li-ming. Epidemiological status and research progress of EV71[J]. Chinese Journal of Maternal and Child Health Research, 2012, 23(5): 681-684. DOI: 10.3969/j.issn.1673-5293.2012.05.049 |
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| Authors: | LIU Xiao-guai LIU Li-ming |
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| Affiliation: | 1 ( 1. First Affiliated Hospital of Medical College, Xi＇ an Jiaotong University Shaanxi Xi＇ an 710061, China; 2. Department of Infectious Diseases, Xi＇ an Children＇ s Hospital, Shaanxi Xi＇ an 710061, China ) |
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| Abstract: | With the wide spread of hand foot and mouth disease （HFMD）, countries around the world are increasingly concerned about it. The disease is mainly caused by EV71 infection. EV71 has the characteristics of addicted to skin and nerve. It can not only induce HFMD and herpangina, but cause serious nervous system diseases and even death. The major clinical manifestations include aseptic meningitis, brainstem encephalitis, neurogenic pulmonary edema, poliomyelitis-like paralysis and other nervous system diseases. How to alleviate patients＇ symptoms and find an effective treatment is the key to prevention. The pathogenesis of EV71 infection, different clinical manifestations, viral genotype and HFMD vaccine need further study. |
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| Keywords: | hand foot and mouth disease （HFMD） EV71 virus epidemiology genotype |
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