| 11β-HSD1对下丘脑-腺垂体-肾上腺轴及海马的影响 |
| |
| 引用本文： | 欧杨,李启富. 11β-HSD1对下丘脑-腺垂体-肾上腺轴及海马的影响[J]. 国际内分泌代谢杂志, 2006, 26(2): 138-140 |
| |
| 作者姓名： | 欧杨 李启富 |
| |
| 作者单位： | 400016,重庆医科大学附属第一医院内分泌科;400016,重庆医科大学附属第一医院内分泌科 |
| |
| 摘 要： | 糖皮质激素(GC)受11β-羟类固醇脱氢酶(HSD)1的调节,对大脑活动产生广泛的影响。11-βHSD1催化无活性的11-脱氧皮质酮转化为有活性的GC,从而提高组织局部的GC浓度,加强GC的作用。GC对下丘脑—腺垂体—肾上腺轴的负反馈调节作用受11-βHSD1的影响。海马是与认知、学习、记忆功能密切相关的重要脑区,极易受到随年龄增加的GC神经毒性的损伤。11-βHSD1活性降低有助于减轻与年龄相关的认知障碍。
|
| 关 键 词： | 11β-羟类固醇脱氢酶Ⅰ型 海马 糖皮质激素 下丘脑-垂体-肾上腺轴 |
| 收稿时间： | 2005-04-11 |
| 修稿时间： | 2005-04-11 |
The effect of 11beta-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis and hippocampus |
| |
| OU Yang,LI Qi-fu. The effect of 11beta-hydroxysteroid dehydrogenase type 1 on hypothalamic-pituitary-adrenal axis and hippocampus[J]. International JOurnal of Endocrinology and Metabolism, 2006, 26(2): 138-140 |
| |
| Authors: | OU Yang LI Qi-fu |
| |
| Affiliation: | Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China |
| |
| Abstract: | Glucocorticoids(GC) affects a wide range of processes in the brain,and is regulated by 11beta-hydroxysteroid dehydrogenase type 1.11beta-hydroxysteroid dehydrogenase type 1 catalyzes inert 11-dehydrocorticosterone to its active glucocorticoids,elevates the concentration of glucocorticoids in the regional tissue and strengthens its effect.11beta-hydroxysteroid dehydrogenase type 1 can influence the negative feedback action of glucocorticoids on the hypothalamic-pituitary-adrenal axis.Hippocampus is an importanct encephalic region closely related to recognition,learning,memory,and is particularly vulnerable to the neurotoxicity of age-related glucocorticoid.Reduction of the activity of 11beta-hydroxysteroid dehydrogenase type 1 can lessen age-related cognitive impairments. |
| |
| Keywords: | 11Beta-hydroxysteroid dehydrogenase type 1 Hippocampus Glucocorticoid Hypothalamic-pituitary-adrenal axis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
