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Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives |
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| Authors: | Kuk Hyun Shin Eun Bang Lee Sang Woo Park Kye Jung Shin Dong Chan Kim Dong Jin Kim |
| Affiliation: | (1) Division of Applied Sciences, Korea Institute of Science and Technology, 136-791 Seoul, Korea;(2) Natural Products Research Institute, Seoul National University, 28, Yeonkeun Dong Chongro-Ku, 110-460 Seoul, Korea |
| Abstract: | The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R′ position contributes to the analgesic activity. |
| Keywords: | Phenoxyalkanoic acid derivatives Anti-inflammatory activity Analgesic activity Carrageenin-induced paw edema Acetic acid writhing syndrome Tail clip pressure test |
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