N-myristoyltransferase: A potential novel diagnostic marker for colon cancer |
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| Authors: | Anuraag Shrivastav Shailly Varma Anurag Saxena John DeCoteau Rajendra K Sharma |
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| Affiliation: | (1) Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada, S7N 5E5;(2) Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Canada, S7N 4H4;(3) Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Canada, S7N 5E5 |
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| Abstract: | Background Colon cancer is the second leading cause of cancer deaths in the western world. If detected early, colorectal cancer is one of the most treatable forms of cancer. Unfortunately, very few people are screened. N-myristoyltransferase (NMT) catalyzes myristoylation of various proteins including oncoproteins. We have demonstrated earlier the alteration of NMT activity during the progression of colorectal cancer and established NMT as a putative therapeutic target for cancer. |
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