H型高血压患者血浆ET-1、vWF因子变化的相关研究

【目的】本研究通过测定H型高血压患者血浆中内皮素-1（Endothelin-1,ET-1）、血管性血友病因子（Von Willebrandfactor,vWF）的水平变化,初步探讨H型高血压血管内皮损伤的状态。【方法】将70例H型高血压患者根据血同型半胱氨酸水平分为两组,中度升高组34例,男18例,女16例;轻度升高组36例,男19例,女17例。再选取20例单纯高血压组,其中男11例,女9例;另选健康体检者18例,其中男9例,女11例作为正常对照。采取所有受试者空腹肘静脉血,应用酶联免疫吸附法（ELISA）测定血浆ET-1、vWF分子标志物水平。【结果】（1）H型高血压组血浆ET-1、vWF水平均高于单纯高血压组（P〈0.05）,并高于正常组（P〈0.05）;（2）同型半胱氨酸中度升高组血浆ET-1、vWF均高于轻度升高组（P〈0.05）。【结论】（1）H型高血压患者血浆ET-1、vWF水平明显增高,表明存在血管内皮损伤;（2）H型高血压组随着血同型半胱氨酸水平的升高,血浆ET-1、vWF水平增高,提示高同型半胱氨酸血症加重血管内皮损伤,增加血管性疾病发生的危险性。

Research about the variations of plasma ET-1 and vWF factor in H-hypertensive patients

【Objective】The purpose of this study was to preliminarily discuss the status of H-hypertensive vascular endothelial injury by measuring the variations of plasma endothelin-1（Endothelin-1,ET-1） and von Willebrand factor（vWF） in H-hypertensive patients.【Methods】70 cases of H-hypertensive patients were divided into a moderately elevated group（34 patients including 18 males and 16 females） and a mildly elevated group（36 patients including 19 males and 17 females）,in accordance with plasma homocysteine levels.Then 20 patients with simple hypertension（11 males and 9 females） and 18 healthy subjects（9 males and 11 females） were selected as control groups.Fasting venous blood was taken from all subjects,and then the levels of plasma ET-1 and vWF molecular markers were measured through enzyme-linked immunosorbent assay（ELISA）【.Results】（1） The levels of plasma ET-1 and vWF in H-hypertensive patients were both higher than those in the hypertensive group（P 0.05） and the normal group（P 0.05）;（2） The levels of plasma ET-1 and vWF in homocysteine group were higher than those in mildly elevated group（P 0.05）.【Conclusions】（1） The levels of plasma ET-1 and vWF in H-hypertensive patients were significantly higher,indicating the presence of vascular endothelial injury;（2） The increase of plasma ET-1 and vWF levels was accompanied by the elevation of plasma homocysteine levels in H-type hypertension group,suggesting that high homocysteine hyperlipidemia would deteriorate the situation of the vascular endothelial damage,and increase the risk of the vascular disease