| 生物反应调节剂（BRM－102）冲剂诱变和抗诱变作用的研究 |
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| 引用本文： | 史天良,刘维兰,郑启英,刘玉瑛,景俊杰,李小玲. 生物反应调节剂（BRM－102）冲剂诱变和抗诱变作用的研究[J]. 肿瘤研究与临床, 1996, 0(3) |
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| 作者姓名： | 史天良 刘维兰 郑启英 刘玉瑛 景俊杰 李小玲 |
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| 作者单位： | 山西省肿瘤研究所 |
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| 摘 要： | 采用微核法对生物反应调节剂冲剂（ＢＲＭ－１０２）的诱变和抑制诱变作用进行了研究。结果显示ＢＲＭ－１０２提取液各种浓度组与阴性对照组统计学处理无意义，表明该冲剂尚未有诱发正常人淋巴细胞微核率升高的作用，不致引起体细胞遗传损伤；对诱变剂丝裂霉素Ｃ诱发正常人淋已细胞微核率有明显的抑制作用。
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| 关 键 词： | 微核，丝裂霉素C，淋巴细胞，生物反应调节剂 |
EXPERIMENTAL STUDY ON THE MUTAGENESIS AND ANTIMUTAGENESIS EFFECT OF BIOLOGICAL RESPONSE MODIFIERS |
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| Shi Tianliang,Liu Weilan,Zheng Qiying,et al. EXPERIMENTAL STUDY ON THE MUTAGENESIS AND ANTIMUTAGENESIS EFFECT OF BIOLOGICAL RESPONSE MODIFIERS[J]. Cancer Research and Clinic, 1996, 0(3) |
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| Authors: | Shi Tianliang Liu Weilan Zheng Qiying et al |
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| Abstract: | The indued mutagcnesis and antiinduced mutagenesis effect of biologicalrcsuonsc modifiers( BRM-102 )by micronucleus test were studied.There were no differencesbetwecn the tcst group and normal control.There wcre significant diffcrences bctween the tcstgroup and positive control.The result showed that BRM-102 did not increase micronuclcus ofnormal human lymphOcyte and it can rcstrain the induccd effect of Mitomycin-C. |
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| Keywords: | Micronucleus Mitomycin-C Lymphoeyte Biological rosposc modifiers |
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