精神发育迟滞高发村病因学研究

目的　探讨智力低下患者精神发育迟滞 (Mental Retardation MR)的原因。　方法　对大庸市汪家山村原因不明的智力低下 (包括智残 )患者 71例 ,34例正常人作为对照研究 ,进行细胞遗传学及淋巴细胞微核率检测。　结果　细胞遗传学检查未发现异常。而对该村 71例智力低下的患者自发性淋巴细胞微核检出率明显高于同村的正常人 (P<0 .0 0 5 ) ,有显著性差异。且该村的正常人与长沙地区正常人的比较亦有显著性差异 (P<0 .0 0 5 )。　结论　该村 MR患者不是由于染色体异常所致 ,MR与环境中某些因素有关 ,因此有必要对汪家山村进行环境改造

Etiology Research on Mental Retardation in High Prevalence Village

Objective To evaluate the cause of mental retardation. Methods 71(14.1% of the whole population in the village) patients were studied by cytogenetics. 34 healthy people (IQ70) were investigated at the same time as control. Result Aberration on cytogenetic analysis was not found. But the lymphocytes micronucleus rate was significantly higher in 71 patients than in 34 healthy people (P<0.005). Furthermore, there was significant difference in healthy people between the village and Changsha City(P<0.005). Conclusion It is the envivomental factor that results in mental retardition rather than chromosome aberration. It is urgent to improve the envivoment of WangJiashan Village.