| 广西首例心脏移植术后环孢素A的药物监测 |
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| 引用本文： | 熊凤英,吴敏,吴洪文,梁陈方.广西首例心脏移植术后环孢素A的药物监测[J].中国现代应用药学,2005,22(6):477-479. |
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| 作者姓名： | 熊凤英 吴敏 吴洪文 梁陈方 |
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| 作者单位： | 广西医科大学第四附属医院药剂科,广西,柳州,545005 |
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| 摘 要： | 目的 建立我院首例心脏移植术后环孢素A血药浓度监测方法，分析药物浓度与剂量、疗效的关系，建立最佳给药方案。方法 运用高效液相色谱法以环孢素B为内标、214nm处紫外检测，对心脏移植受者进行环孢素A血药浓度监测，并及时给予用药剂量调整。结果 该患者至今存活，生活质量良好，环孢素A血药浓度控制得很好。结论 高效液相色谱法能满足环孢素A的临床常规血药浓度监测需求。
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| 关 键 词： | 心脏移植 环孢素A 药物浓度监测 高效液相色谱法 |
| 文章编号： | 1007-7693（2005）06-0477-03 |
| 收稿时间： | 2004-05-19 |
| 修稿时间： | 2004-05-19 |
Therapeutic drug monitoring of cyclosporin-A after the first heart transplantation in GUANGXI |
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| XIONG Feng-ying,WU Min,WU Hong-wen,LIANG Chen-fang.Therapeutic drug monitoring of cyclosporin-A after the first heart transplantation in GUANGXI[J].The Chinese Journal of Modern Applied Pharmacy,2005,22(6):477-479. |
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| Authors: | XIONG Feng-ying WU Min WU Hong-wen LIANG Chen-fang |
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| Institution: | Department of Pharmacy, Fourth Affiliated Hospital, Guangxi Medical University, Liuzhou 545005, China |
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| Abstract: | OBJECTIVE To develop a method for determination of cyclosporine-A in blood after the first heart transplanation in our hospital,and analyse the relation between dosage,clinical effect and concentration,finally to develop a best curing scheme.METHODS An HPLC was used with cyclosporine-B as the internal standard and detected at 214 nm.Determinate the patient's blood concentration of cyclosporine-A and adjust the dosage in time. RESULTS The patient is still alive with a good life and the blood concentration of cyclosporine-A was under well control.CONCLUSION HPLC can satisfy the demand of general clinic determination of blood concentration of cyclosporine-A. |
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| Keywords: | heart transplantation cyclosporine-A TDM HPLC |
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