膝关节液pH值与痛风结晶的形成

背景：引起痛风结晶析出的原因除了尿酸盐浓度升高之外还应有其他的影响因素。目的：探讨膝关节液pH值在痛风结晶形成中的意义。方法：选择2008-08/2010-12桂林医学院附属医院脊柱骨病外科因膝关节疾病就诊的患者40例,分为2组,实验组：关节镜检见关节内白垩样结晶沉积者。对照组：关节镜检关节内无明显白垩样结晶形成。其中实验组膝关节液25份,对照组膝关节液15份。检测并比较两组患者的关节液pH值。结果与结论：实验组pH值7.8±0.2,对照组pH值8.5±0.3。镜检有痛风结晶形成的膝关节液pH值较无痛风结晶形成的膝关节液pH值明显偏低,差异有显著性意义（P〈0.001）。提示有痛风结晶形成的膝关节液pH值较无痛风结晶形成的膝关节液pH值明显偏酸性,膝关节液pH值降低是痛风结晶析出的危险因素之一。

Meaning of pH value of the knee joint fluid in the crystal formation of gout

BACKGROUND：There should be other factors influencing crystallization of gout besides increase of uric acid concentration OBJECTIVE：To explore the meaning of pH value of the knee joint fluid in the crystal formation of gout.METHODS：We tested and compared the pH values of experiment group（25 hyperuricemia patients,with gout crystals in joint fluid） and control group（15 hyperuricemia patients,without gout crystals in joint fluid）.RESULTS AND CONCLUSION：The pH value of experiment group（7.8±0.2） was less than that of control group（8.6±0.3）.The pH value of the knee joint fluid of patients with gout crystals in their knee joint was significantly lower than that of patients without gout crystals in their knee joint（P 0.001）.The lower pH value of the knee joint fluid,the more possibility of gout crystals.Low pH value of the knee joint fluid is one of the risk factors for crystallization of gout.