SDF-1/CXCR4信号通路在骨性关节炎病理进程中的作用

背景：骨性关节炎的发病机制错综复杂,其预防与治疗是当今医学界的难题之一,与其相关的信号通路的研究已成为国内外研究的热点,其靶向治疗有望成为攻克骨性关节炎的关键。目的：总结SDF-1/CXCR4信号通路在诸多疾病尤其是在骨性关节炎发病中的作用,为骨性关节炎的靶向治疗提供科学依据。方法：应用计算机检索PubMed和CBM数据库中2008-09/2010-07发表的相关文献。以主题检索为主要检索方法,结合限定检索等方法,以＂SDF-1/CXCR4信号通路、骨性关节炎＂和＂SDF-1/CXC4 signaling pathway,osteoarthritis＂为中英文检索词,选择与骨性关节炎SDF-1/CXCR4信号通路有关的文献,排除内容陈旧、重复的文章。结果与结论：共检索到2147篇文章,按纳入和排除标准对文献进行筛选,保留32篇文章进行综述。目前,SDF-1/CXCR4信号通路在诸多疾病的发生发展过程中具有重要作用,已成为目前世界医学的研究热点之一。有研究表明,SDF-1/CXCR4信号通路可能在骨性关节炎的发病中具有重要作用,而对该信号通路的干预可能成为预防与治疗骨性关节炎的靶点,有望成为今后骨性关节炎防治方面研究的热点。

Role of SDF-1/CXCR4 signaling pathway in pathogenesis of osteoarthritis

BACKGROUND：The pathogenesis of osteoarthritis（OA） is very complex,the prevention and treatment of OA is a medical challenge,and the signaling pathway related to OA is becoming the hot spot of current researches.The targeted therapy may be the key to treat OA.OBJECTIVE：To discuss the role of SDF-1/CXCR4 signaling pathway in many diseases and the pathogenesis of OA,and to provide the basis of targeted therapy on OA.METHODS：CBM and PubMed were retrieved by computer using of ＂SDF-1;CXCR4 signaling pathway;Osteoarthritis＂ both in Chinese and English,with the method of subject index combined with limited index.The papers which included the two themes were accepted,and those which had old and duplicate contents were excluded.RESULTS AND CONCLUSIONS：Of 2 147 retrieved articles,only 32 papers were involved in result analysis.SDF-1/CXCR4 signaling pathway,with its important role in many diseases,is becoming the research focus of current medical associates.SDF-1/CXCR4 signaling pathway possibly has important effect on OA.The targeted therapy on OA may be the key of the treatment of OA.