基于流体动力学模拟腹腔温热化疗仪系统的设计

背景：腹腔温热化疗仪应用区域大剂量化疗和温热的协同作用，诱导腹腔内肿瘤癌细胞发生凋亡和坏死，其临床疗效已得到各国学者肯定。然而，当前国内腹腔温热化疗仪温度控制精度低，治疗效果不理想，无法满足治疗需求。目的：基于F2812及流体动力学仿真模拟，讨论了一种腹腔温热化疗仪的系统设计，以期优化参数，达到最佳温度控制精度，利用流体动力学仿真为最佳手术实施布管策略提供数值模拟数据。方法：基于F2812芯片的DSP控制器可快速响应控制加热及循环系统，提高系统温度控制精度。通过PID参数整定得到最佳控制参数：通过流体动力学仿真实验，模拟术中腹腔温度场及速度矢量场，优化腹腔布管策略。流体动力学仿真采用FLUENT软件，讨论了3种常见术中腹腔布管方式，并给出术中腹腔温度场分布。结果与结论：设计了可提高系统温度精度的温度采集控制模块。系统温度控制精度±0.3℃。通过FLUENT仿真结果发现闭腔三进两出方式即可满足治疗要求，并给出三维腹腔温度场分布情况。

System design for an intraoperative peritoneal hyperthermia chemotherapy machine based on computational fluid dynamics simulation

BACKGROUND： Introperative peritoneal hyperthermia chemotherapy （IPHC） using interaction of regional high-dose chemotherapy and hyperthermia induce apoptosis and necrosis of intraoperative tumor cells. Its clinical effect has been confirmed around the world. However, current IPHC machine has low control accuracy and its therapeutic efficacy is not ideal. OBJECTIVE： To design a kind of IPHC machine system based on F2812 and computational fluid dynamics （CFD） simulation and optimize its parameters to have best temperature control and therapeutic effects. METHODS： Control system of heating and circulation based on DSP F2812 had fast response and high temperature control accuracy. Optimize parameter could be obtained by tuning PID algorithm. CFD simulation of Intraperitoneal temperature field and velocity vector field were calculated by FLUENT. Three kind of introperative peritoneal piping mode were compared to find the best strategy. Peritoneal temperature distribution was given, RESULTS AND CONCLUSION： The temperature acquisition and control module was designed, and the temperature control accuracy was±0.3℃. Optimization results showed that 3 inflows and 2 outflows with closed cavity can meet operation requirements. Peritoneal temperature distribution in 3D is also given.