| 体外培育牛黄与天然牛黄指纹图谱的比较研究 |
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| 引用本文： | 丁岗,盛龙生,李明慧,张弦,蔡宝昌.体外培育牛黄与天然牛黄指纹图谱的比较研究[J].中国天然药物,2004,2(5):309-312. |
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| 作者姓名： | 丁岗 盛龙生 李明慧 张弦 蔡宝昌 |
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| 作者单位： | 1. 江苏中康药物科技有限公司,南京,211100
2. 中国药科大学分析测试中心,南京,210009 |
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| 摘 要： | 目的：研究、比较体外培育牛黄与天然牛黄的指纹图谱。方法：利用TOFMS、HPIEJMS技术研究、比较体外培育牛黄与天然牛黄中肽类、胆汁酸类和胆红素类3类成分的指纹图谱。结果：体外培育牛黄与天然牛黄3类成分的指纹基本一致，但各成分间的相对含量有差异。结论：10批体外培育牛黄的指纹图谱有较好的一致性，说明体外培育牛黄的质量稳定。4批天然牛黄的指纹图谱，尤其是胆汁酸类成分的指纹图谱差异明显，说明天然牛黄由于来源不同，导致质量不够稳定.
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| 关 键 词： | 体外培育牛黄 指纹图谱 天然 胆汁酸 肽类 胆红素 成分 相对含量 |
| 文章编号： | 1672-3651(2004)05-0309-04 |
| 修稿时间： | 2004年5月19日 |
Comparative Study on Fingerprints of Cultured and Natural Calculus Bovis |
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| DING Gang ,SHENG Long Sheng ,LI Ming Hui ,ZHANG Xian ,CAI Bao Chang Jiangsu Zhongkang Pharmaceutical Sci and Tech Inc,Nanjing , Center for Instrumental Analysis,China Pharmaceutical University,Nanjing ,China.Comparative Study on Fingerprints of Cultured and Natural Calculus Bovis[J].Chinese JOurnal of Natural Medicines,2004,2(5):309-312. |
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| Authors: | DING Gang SHENG Long Sheng LI Ming Hui ZHANG Xian CAI Bao Chang Jiangsu Zhongkang Pharmaceutical Sci and Tech Inc Nanjing Center for Instrumental Analysis China Pharmaceutical University Nanjing China |
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| Institution: | DING Gang 1,SHENG Long Sheng 2,LI Ming Hui 1,ZHANG Xian 1,CAI Bao Chang 1 1 Jiangsu Zhongkang Pharmaceutical Sci and Tech Inc,Nanjing 211100, 2 Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM: To study the fingerprints of cultured and natural Calculus Bovis METHOD:Analysis and comparison were made for the fingerprints of peptides,bile acids and bilirubins of cultured and natural Calculus Bovis by using TOFMS and HPLC/MS techniques RESULT:The fingerprints of peptides,bile acids and bilirubins of cultured Calculus Bovis were similar to those of natural Calculus Bovis,but differences exist in the relative content of each constituent CONCLUTION:The fingerprint repeatability of 10 batches cultured Calculus Bovis indicated that the quality of cultured Calculus Bovis was constant The fingerprints of 4 batches natural Calculus Bovis,especially the fingerprints of bile acids revealed that the quality of natural Calculus Bovis was not constant because of different origins |
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| Keywords: | Cultured Calculus Bovis Natural Calculus Bovis Peptides Bile acids Bilirubins Fingerprints |
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