|
|||||
|
|
| 肾脏细胞外基质降解的分子机制及中药的干预作用 | |
| 引用本文： | 魏晴雪,万毅刚,赵青,陈好利,孟宪杰,姚建. 肾脏细胞外基质降解的分子机制及中药的干预作用[J]. 中国中药杂志, 2013, 38(4): 533-538 |
| 作者姓名： | 魏晴雪 万毅刚 赵青 陈好利 孟宪杰 姚建 |
| 作者单位： | 1. 南京中医药大学中西医结合鼓楼临床医学院,江苏南京,210029 2. 南京大学医学院附属鼓楼医院中医科,江苏南京,210008 3. Department of Molecular Signaling University of Yamanashi,Japan Yamanashi 409-3898 |
| 基金项目： | 南京市卫生青年人才培养工程项目;江苏高校优势学科建设工程项目 |
| 摘 要： | 肾脏细胞外基质(extracellular matrix,ECM)降解减少是慢性肾脏病(chronic kidney disease,CKD)肾组织损伤的形态特征和病理基础.在肾小球或肾间质中,ECM降解主要依赖于降解酶系统的调控,其中,基质金属蛋白酶(matrix metalloproteinases,MMPs)发挥着核心作用.MMPs的表达和活性受控于“基因转录、酶原激活、特异性抑制剂”等经典途径.以尿毒清颗粒(Uremic Clearance granule)为代表的中药复方制剂及中药提取物可以干预ECM降解的多种途径,包括促进ECM成分降解,影响ECM降解酶表达、调节MMPs基因转录、抑制MMPs相关信号转导等. |
| 关 键 词： | 慢性肾脏病 细胞外基质 基质金属蛋白酶 中药 |
| 收稿时间： | 2012-07-15 |
Molecular mechanisms of renal extracellular matrix degradation and interventional effects of Chinese herbal medicine |
|
| WEI Qing-xue,WAN Yi-gang,ZHAO Qing,CHEN Hao-li,MENG Xian-jie and YAO Jian. Molecular mechanisms of renal extracellular matrix degradation and interventional effects of Chinese herbal medicine[J]. China Journal of Chinese Materia Medica, 2013, 38(4): 533-538 | |
| Authors: | WEI Qing-xue WAN Yi-gang ZHAO Qing CHEN Hao-li MENG Xian-jie YAO Jian |
| Affiliation: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Department of Molecular Signaling University of Yamanashi, Yamanashi 409-3898, Japan |
| Abstract: | |
| Keywords: | chronic kidney disease extracellular matrix matrix metalloproteinases Chinese herbal medicine |
| 本文献已被 万方数据 等数据库收录！ | |