| 家兔EP性发热时血浆、脑脊液和不同脑区组织cAMP含量的变化 |
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| 引用本文： | 徐方云,李楚杰. 家兔EP性发热时血浆、脑脊液和不同脑区组织cAMP含量的变化[J]. 中国病理生理杂志, 1997, 0(1) |
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| 作者姓名： | 徐方云 李楚杰 |
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| 作者单位： | 江西医学院病理生理教研室(徐方云)，暨南大学医学院病理生理教研室(李楚杰) |
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| 摘 要： | 用封闭群新西兰白兔６０只，观察比较家兔ＥＰ性发热时血浆、脑脊液和不同脑区组织中ｃＡＭＰ的含量的变化。结果发现：家兔ＥＰ性发热时，下丘脑和脑脊液的ｃＡＭＰ含量明显升高，到达热限时，两者的ｃＡＭＰ含量增长同时受限，两者间的ｃＡＭＰ含量变化呈显著的正相关（ｒ＝０．９８５，Ｐ＜０．０１），而血浆、脑干及皮层ｃＡＭＰ含量无明显改变，据此，作者推论：（１）ＥＰ性发热时下丘脑ｃＡＭＰ含量的嵲龆嗍悄约挂海悖粒停性龆嗟闹饕丛矗唬ǎ玻┫虑鹉裕悖粒停泻吭龀な芟奘牵牛腥认薜闹匾梢颉
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| 关 键 词： | 发热，腺苷环一磷酸，下丘脑，家兔 |
Change .of cAMP content ,in brain tissue, cerebrospinal fluid (CSF) and plasma during endogenous pyrogen (EP) fever in rabbits- |
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| Xu Fang - Yun,Li Chu. Jie. Change .of cAMP content ,in brain tissue, cerebrospinal fluid (CSF) and plasma during endogenous pyrogen (EP) fever in rabbits-[J]. Chinese Journal of Pathophysiology, 1997, 0(1) |
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| Authors: | Xu Fang - Yun Li Chu. Jie |
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| Affiliation: | Xu Fang - Yun,Li Chu. Jie. Department of Pathophysiology,Jiangxi Medical College,Nanchang |
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| Abstract: | ln order to study the mechanisms of EP fever limit and the sources of cAMP in CSF respond to ,EP fever, the expeiments were carried out with 60 rab- bits to observe the changes of cAMP contents in different regions of brain, tissue, CSF and plasma during EP fever. The results ,demonstrated that: (1) A significant increase of cAMP content in hypothalamus and CSF was induced by EP, but was limited by EP fever limit while tbere were no obvious changes of cAMP content in brain -stem, brain - cortex and plasma; (2) The response of cAMP in CSF, was apparently paralleled and correlated with that in hypothalamus , and the febrile reac- tion (r=0.985, P<0.01; r=0.999, p<0,.00l) Authors dedueed from the above: The increase of cAMP content in CSF was mainly come from that of hypothalamus: The limit of cAMP increase in hypothalamus might be an important contributing factor in fever limit of EP, , |
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| Keywords: | MeSH Fever . Adenosine cyclic monophosphate . Hypothalamus . Rabbits |
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