Kappa-晒化卡拉胶对实验动物的抗心律失常作用

Kappa-硒化卡拉胶是一含硒有机化合物。ip 9 mg·kg^-1·d^-1×5d或单次ig 35,70,140mg·kg^-1能显著提高乌头碱致大鼠HA的阈剂量,此作用可与Na₂SeO₃ 1 mg·kg^-1·d^-1×5d ip比拟.随着Kappa-硒化卡拉胶ig剂量增加,尚可提高乌头碱所致VE,VT和VF的阈剂量。ip 9mg·kg^-1·d^-1×5 d或ig 70mg·kg^-1能提高BaCl₂致大鼠或哇巴因致豚鼠HA的阈剂量。对BaCl₂致大鼠VF或哇巴因致豚鼠VE的阈剂量,分别在ig70mg·kg^-1与140mg·kg^-1时有提高,而ipNa₂SeO₃ 1 mg·kg^-1·d^-1×5d无此明显影响。

ANTIARRHYTHMIC EFFECTS OF KAPPA-SELENOCARRAGEENAN IN EXPERIMENTAL ANIMALS

The effect of Kappa-seleno-carrageenan, an organic compound containing selenium, on aconitine, BaCl2 and ouabain-induced arrhythmias were studied. When rats were given ip 9 mg.kg-1.d-1 x 5 d or ig single dose of 35, 70, 140 mg.kg-1, the threshold dose of aconitine was elevated significantly to induce HA. The effect seems to resemble that of ip Na2SeO3 1 mg.kg-1 x d-1 x 5 d. With increasing ig dose, the threshold dose of aconitine was elevated for inducing VE, VT, VF. When ip 9 mg.kg-1 x d-1 x 5 d or ig 70 mg.kg-1 was given, the threshold doses of BaCl2 in inducing VF (in rats) and ouabain in inducing VE (in guinea-pig) were elevated. However, no influence was observed for ip Na2SeO3 1 mg.kg-1 x d-1 x 5 d.