Toxicologic and pharmacologic properties of tolnaftate,an antitrichophyton agent

Tolnaftate (naphthiomate-T), a new antitrichophyton agent, has received toxicologic and pharmacologic investigation. The acute toxicity of tolnaftate for several species by different routes of administration was very slight, there being a death rate of 410 role=presentation style=font-size: 90%; display: inline-block; position: relative;>$\text{4}\text{10}$$\text{4}\text{10}$ in mice by the intraperitoneal injection of 8 and 10 g/kg of the agent. By subacute toxicity studies in mice and dogs, there was neither a marked effect on body weight gain, nor any gross signs of toxicity. No significant observations were made by gross and microscopic examination of tissues. Repeated skin applications and short-term oral toxicity studies were conducted in rabbits. No skin irritation resulted from repeated application of the drug. During the studies of repeated oral doses in rabbits, clinical observations, hematologic data, organ function values, urinalyses, and terminal gross and microscopic examinations of tissues were obtained. No evidence of drug effect was observed in rabbits that received daily oral doses of 2500 mg/kg or less for 91 consecutive days.Tolnaftate did not exhibit significant activity in any of the pharmacologic tests such as its actions on the central nervous system, cardiovascular and respiratory systems, peripheral systems, and blood.