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| 微调三号方对小鼠大肠癌肝转移灶基质金属蛋白酶-2及金属蛋白酶组织抑制因子-2的影响 | |
| 引用本文： | 王旺胜,尤建良,浦琼华. 微调三号方对小鼠大肠癌肝转移灶基质金属蛋白酶-2及金属蛋白酶组织抑制因子-2的影响[J]. 中西医结合肝病杂志, 2011, 21(3): 159-161. DOI: 10.3969/j.issn.1005-0264.2011.03.012 |
| 作者姓名： | 王旺胜 尤建良 浦琼华 |
| 作者单位： | 无锡市中医院肿瘤科,江苏无锡,214001 |
| 基金项目： | 无锡市科技局、卫生局指令性课题 |
| 摘 要： | 目的：探讨微调三号方（WD-3）对小鼠大肠癌肝转移灶基质金属蛋白酶-2（MMP-2）及金属蛋白酶组织抑制因子-2（TIMP-2）的影响。方法：建立BALB/c鼠结肠腺癌肝转移模型,随机分为6组：模型组,西药组,中药低、中、高剂量组,中西药组,分组治疗4周。免疫组化染色结合图像分析系统半定量检测转移灶MMP-2、TIMP-2积分光密度及MMP-2/TIMP-2比值。结果：与模型组比,中西药组及西药组小鼠肝转移灶TIMP-2含量增高,且前者与后者比较,差异有显著性意义（P〈0.05）;中西药组和西药组小鼠MMP-2/TIMP-2比值均降低,与模型组及各中药组比较,差异有显著性意义（P〈0.05）,且中西药组与西药组比较亦有显著性意义（P〈0.05）。结论：微调三号方配合化疗可降低肝转移灶内MMP-2/TIMP-2比值,提示对小鼠大肠癌肝转移可能具有抑制作用。 |
| 关 键 词： | 大肠癌 肝转移 小鼠 微凋三号方/药理作用 基质金属蛋白酶-2 金属蛋白酶组织抑制因子-2 |
Effect of WD-3 on expressions of MMP-2 and TIMP-2 in mouse liver metastases of colorectal cancer |
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| WANG WANG-SHENG,YOU JIAN-LIANG,PU QIONG-HUA. Effect of WD-3 on expressions of MMP-2 and TIMP-2 in mouse liver metastases of colorectal cancer[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 2011, 21(3): 159-161. DOI: 10.3969/j.issn.1005-0264.2011.03.012 | |
| Authors: | WANG WANG-SHENG YOU JIAN-LIANG PU QIONG-HUA |
| Affiliation: | WANG WANG-SHENG,YOU JIAN-LIANG,PU QIONG-HUA.Wuxi Hospital of TCM(Wuxi Jiangsu,214001)China |
| Abstract: | Objective:To study the effect of WD-3 on the expressions of MMP-2 and TIMP-2 in mouse liver metastases of colorectal cancer.Methods: BALB/c mouse of liver metastasis of colon cancer were randomly divided into 6 groups: model group,western medicine group,traditional Chinese medicine(TCM) low,medium and high dose groups,western combined with TCM group.All groups were treated for 4 weeks.Immunohistochemistry staining and image analysis system were applied to determine the expressions of MMP-2 and TIMP-2,moreov... |
| Keywords: | colorectal cancer liver metastases mouse WD-3/pharmacological effect MMP-2 TIMP-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |