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Hypercalcemia in a Case of Childhood Acute Lymphoblastic Leukemia |
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| Authors: | Todo, Shinjiro Imashuku, Shinsaku Inoda, Hiroshi Yamanaka, Hirofumi Hibi, Shigeyoshi Tsunamoto, Kentaro Esumi, Noriko Fujiwara, Fumihiro Shimizu, Yoshitaka Morioka, Yoshihito Sugimoto, Tohru |
| Affiliation: | 1Department of Pediatrics Research Hospital, Kyoto Prefectural University of Medicine Kawaramachi, Kamikyoku, Kyoto 602, Japan 2Department of Pediatrics Research Hospital, Kyoto Prefectural University of Medicine Kawaramachi, Kamikyoku, Kyoto 602, Japan 3Children's Research Hospital, Kyoto Prefectural University of Medicine Kawaramachi, Kamikyoku, Kyoto 602, Japan |
| Abstract: | Severe hypercalcemia (serum calcium, 4.255.25 mmol/l),in association with osteolytic bone lesions, was found in agirl aged 2 yr 7 mo with common acute lymphoblastic leukemia(ALL). Hormonal studies excluded the possibility of the hypercalcemiabeing caused by primary hyperparathyroidism or ectopic parathyroidhormone secretion. Increased plasma prostaglandinE2 (PGE2).Jlevels (130 ng/l), probably produced by leukemic cells, wereconsidered to be one of the pathogenic mechanisms responsiblefor the occurrence of hypercalcemia in this patient. Both thehypercalcemia and the abnormal plasma PGE2 level returned tonormal after chemotherapy. |
| Keywords: | Hypercalcemia Common acute lymphoblastic leukemia Prostaglandin E2 |
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