帕罗西汀合并奥氮平治疗围绝经期抑郁疗效观察

目的:观察帕罗西汀合并小剂量奥氮平治疗围绝经期抑郁症患者的疗效。方法:随机将72例围绝经期抑郁症患者分为帕罗西汀合并小剂量奥氮平治疗组及单用帕罗西汀对照组各36例。两组患者在性别、年龄、病程和HAMD总分等方面,差异均无显著性(P>0.05)。采用HAMD及TESS分别于治疗前和治疗2、6周末进行疗效评定。结果:与治疗前比较,治疗组患者在治疗2、6周末HAMD评分均有显著下降(P<0.01),对照组患者2周末下降明显(P<0.05),6周末下降显著(P<0.01);两组间比较,治疗组患者在2、6周末降分均明显大于对照组(P<0.05)。经6周治疗,治疗组患者显效率86.1%,对照组患者显效率63.8%,治疗组显效率明显高于对照组(P<0.05)。两组患者不良反应主要为头晕、乏力及嗜睡等,两组间TESS评分在2、6周末时均无明显差异(P>0.05)。结论:治疗围绝经期抑郁症患者,帕罗西汀合并小剂量奥氮平的疗效优于且起效快于单用帕罗西汀的治疗,不良反应则相差不大,这有利于提高患者的依从性。

Observation of effects of paroxetine combined olanzapine in treatment of perimenopausal depression

Objective：To observe effects of paroxetine combined with small dose of olanzapine in treatment of perimenopausaldepression. Methods：72 patients with perimenopausal depression random were divided into paroxetine with small dose of olanzapinetreatment group （treatment group, n=36） and paroxetine treatment group （control group, n=36）. For the two groups, there were nodifferences in gender, age, course and HAMD scores, etc. （P〉0. 05）. The effects were evaluated with HAMD and TESS before and2 and 6 weeks after the treatment. Results： The HAMD score of treatment group after the treatment was significantly lower than that be-fore the treatment （P〈0. 01）, while the HAMD score of control group obviously decreased 2 weeks after the treatment （P〈0. 05） andsignificantly decreased 6 weeks after the treatment （P〈0. 01）. 2 and 6 weeks after the treatment, the HAMD scores of treatment groupdecreased significantly than those of control group （P〈0. 05）. 6 weeks after the treatment, the effective rates of treatment group andcontrol group were 86. 1% and 63. 8%, respectively. The adverse reactions of the two groups were mainly dizziness, fatigue, sleepi-ness and so on, and the TESS score between the two groups had no obvious difference 2 and 6 weeks after the treatment （P〉0. 05）.Conclusions： In the treatment of perimenopausal depression, paroxetine combined with small dose of olanzapine are better than paroxe-tine in the effects and works faster. Moreover, the adverse reactions are generally mild, which is beneficial to improve patient compli-ance.