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| 原位心脏移植术后早期的血流动力学实验研究 | |
| 引用本文： | 刘志平,;王亮,;朱宪明,;张玉龙,;王坚,;李淑珍,;赵龙,;郭俊晓,;任杰,;高荣,;邱能庸. 原位心脏移植术后早期的血流动力学实验研究[J]. 疾病监测与控制, 2009, 0(6): 321-324 |
| 作者姓名： | 刘志平, 王亮, 朱宪明, 张玉龙, 王坚, 李淑珍, 赵龙, 郭俊晓, 任杰, 高荣, 邱能庸 |
| 作者单位： | [1]内蒙古医学院第一附属医院胸心外科,内蒙古呼和浩特010059; [2]北京市结核病胸部肿瘤研究所,北京101149 |
| 基金项目： | 内蒙古自治区卫生厅科研基金资助.编号：2006028 |
| 摘 要： | 目的通过心脏移植的实验研究，比较双腔静脉法同种异体原位心脏移植术与全心脏移植法同种异体原位心脏移植术的出血量，移植后心脏的早期血流动力学方面的不同。方法供、受体杂种犬16只，将实验动物分成双腔静脉心脏移植术组和全心脏移植术组，每组各8只，分别在全麻、中度低温体外循环下进行手术。记录术中出血量，术后采用GE—vivid7型彩色多普勒超声诊断仪，心电监护仪观察血流动力学指标。结果5例移植心脏自动复跳（双腔静脉心脏移植术组3例，全心脏移植法组2例），3例移植心脏通过电除颤复跳（双腔静脉心脏移植术组1例，全心脏移植法组2例），双腔静脉法心脏移植与全心脏移植法出血量对比为（475±20．81ml vs 545±26．45ml），术后早期血流动力学参数两组均比较稳定。结论提高手术技术，避免吻合口出血，加强心肌保护是心脏移植手术的关键，双腔静脉法心脏移植在出血量方面少于全心脏移植术，两组心脏移植术后早期血流动力学方面无明显差异。 |
| 关 键 词： | 心脏移植 血流动力学 术式 |
Experimental Research Of Early Hemodynamic Changes After Orthotopic Heart Transplantation |
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| Affiliation: | LIU Zhi-ping, WANG Liang, ZHU Xian-ming, et al. (Department of Cardiothoracic Surgery, Affiliated Hospital, Inner Mongolia Medical College, Huhhot 010050, China) |
| Abstract: | Objectives Through experimental study of canine heart transplanttation ,it was the comparison of blood loss and early hemodynamic changes after, orthotopic homologous heart transplantation between bicaval orthotopic cardiac transplantation and total orthotopic cardiac transplantation. Methods Donor, receptor 16 hybrid dogs.Experimental animal were divided into 2 groups each group 8 dogs.Operations were performed on general anesthesia and moderately low temperature cardiopulmonary bypass. Respectively reported blood loss, postoperation hemodynamies parameters in were observed by GE-vivid7 color doppler ultrasonic diagnostic apparatus and ECG monitor. Results Spontaneous recovery of heart beat occurred in 5 cases （bieaval orthotopic cardiac transplantation group 3cases,total orthotopic cardiac transplantation. Group2 cases） and recovery of heart beat by defibrilltion in 3 cases （bicaval orthotopic cardiac transplantation group leases,total orthotopic cardiac transplantation. Group2 cases）. Espectively blood loss（475±20.81ml vs 545±26.45ml）, postoperative early Hemodynamic parameters were relatively stable Respectively.Conclusion Gentle manipulation , reduce bleeding at anastomosis and improvement of myocardial protection are key to cardiac transplantation. Bicaval orthotopic cardiac transplantation is better than Total orthotopic cardiac transplantation in blood loss. There is not remarkable different in early hemodynamic changes after orthotopic homologous heart transplantation between bicaval orthotopic cardiac transplantation and total orthotopic cardiac transplantation |
| Keywords: | cardiac transplantation hemodynamies operative methods |
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