霉酚酸酯替代硫唑嘌呤在肾移植中的应用

目的 观察霉酚酸酯(MMF)替代硫唑嘌呤(Aza)在预防肾移植术后急性排斥中的作用。方法 回顾性分析我院95例肾移植后应用皮质激素(Perd)，环孢素(CsA)，MMF(或)硫唑嘌呤(Aza)三联免疫抑制剂治疗，其中分成MMF组57例，Aza组38例，MMF组适当减少环孢素用量。结果 MMF组发生急性排斥率为8．89%(5／57)，Aza组为23．7%(9／38)。结论 以MMF代替Aza应用于肾移植术后，可以减少术后急性排斥及CsA的用量，减少药物的肝肾毒性。

Application of mycophenolate mofetil in preventing a cute rejection kidney transplantation

OBJECTIVE To observe the effect of applying mycophenolate mofetil (MMF) instead of azathioprine (Aza) in preventing acute rejection kidney transplantation. METHOD We retrospectively analyzed the data from 95 cases receiving Pred, CsA, MMF/Aza combined immunosuppressant therapy after kidney transplantation in our hospital. They were divided into two groups; the MMF group (57 cases) and the Aza group (38 cases). The cases in the MMF group were given smaller dosage of CsA.RESULTS The acute rejection rate was 8.8%(5/57) in the MMF group, and 23.7%(9/38) in the Aza group. CONCLUSION It is essential to apply MMF instead of Aza on patients after kidney transplantation to reduce acute rejection, give smaller CsA dosage, and alleviate damage to the liver and kidney.