| 药物对颅脑伤小鼠血糖的影响 |
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| 引用本文： | 周玉璞,江基尧,张光霁,朱诚,路红社.药物对颅脑伤小鼠血糖的影响[J].第二军医大学学报,1999,20(8):563-564. |
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| 作者姓名： | 周玉璞 江基尧 张光霁 朱诚 路红社 |
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| 作者单位： | 第二军医大学长海医院肿瘤科,上海,200433;第二军医大学长征医院神经外科,开封高等医学专科学校淮河医院神经外科 |
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| 基金项目： | 军队“八五”医学科研规划基金 |
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| 摘 要： | 目的：探讨药物对颅脑伤后血糖水平的影响。方法：采用颅脑外伤液压致伤装置制作颅脑伤动物模型，动态观察药物对血糖水平的影响。结果：(1)地塞米松＋10％葡萄糖＋胰岛素药物组和地塞米松＋20％甘露醇＋胰岛素组，对颅脑伤后的高血糖具有治疗作用。(2)单纯应用20％甘露醇，在72 h内对颅脑伤大鼠具显著的降血糖作用。(3)纳络酮能够显著降低颅脑伤大鼠的血糖含量，给药后24 h作用最为显著，72 h时仍能维持很好的疗效。结论：甘露醇、纳络酮和适度的pH值，对颅脑伤动物具有降血糖作用。
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| 关 键 词： | 脑损伤 血糖 |
Relationship between the drugs and blood sugar after brain injury in rats |
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| Lu Hongshe,Zhu Cheng,Zhang Guangji,Jiang Jiyao,Zhou Yupu.Relationship between the drugs and blood sugar after brain injury in rats[J].Academic Journal of Second Military Medical University,1999,20(8):563-564. |
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| Authors: | Lu Hongshe Zhu Cheng Zhang Guangji Jiang Jiyao Zhou Yupu |
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| Abstract: | Objectve: To study the relationship between the drugs and blood sugar(BS) after brain injury. Methods: The effect of usual drugs which treating brain injury(BI) on BS was observed in rats after head injury.Results: (1)The group of dexamethasonum + 10% glucose + insulin, and the group of dexamethasonum + 20% mannitolum + insulin were effective for treating high BS after drug injection. (2)20% mannitolum was effective for treating high BS after drug injection. (3)Naloxone could markedly decrease BS. Conclusion: The drugs of mannitolum, naloxone and certain pH could decrease blood sugar in brain injury animals |
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| Keywords: | brain injuries blood sugar |
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