肝纤维化MRI弥散加权成像的初步研究

目的 探讨MRI扩散加权成像对肝纤维化的诊断价值.方法 分别对54例经肝穿刺活检确诊的肝纤维化病人利用扩散加权成像技术分别测定b值为300、500、700s/mm2时的表观扩散系数(ADC值).比较各组ADC值的变化情况,并与病理改变作对照研究.结果 b值取500和700s/mm2时,随肝纤维化分期的增加,ADC值依次...

Preliminary Study on MRI Diffusion-Weighted Imaging of Liver Fibrosis

Objective To evaluate diagnostic value of diffusion-weighted MRI for hepatic fibrosis.Methods Apparent diffusion coefficient(ADC)values of 54 patients with liver fibrosis proved by liver biopsy were measured by diffusion-weighted imaging when the b values were 300,500,700s/mm2 respectively.The change of ADC value in a group was compared with other groups,and it was also compared with corresponding pathological change as a control study.Results When b value was 500 and 700s/mm2,with liver fibrosis stage increasing,ADC values were gradually reduced,and a good negative correlation(P <0.01)appeared between ADC values and liver fibrosis stage;While the b value was 300s/mm2,good correlation between ADC values and liver fibrosis stage was not showed(P> 0.05).By group comparison,S0-S3 stage could be distinguished with S4 stage by ADC values when b value was 300s/mm2;when b value was 500s/mm2,S0 could be distinguished with S2 and S4 respectively,and S1 could be distinguished with S2;when b value was 700s/mm2,S0,S1 could be distinguished with S2,S3 and S4 respectively.Conclusion In case of choosing a suitable b-value,it is an effective imaging diagnostic method to measure ADC values by MRI diffusion-weighted imaging for the detection of liver fibrosis and early cirrhosis.