雷贝拉唑治疗幽门螺杆菌阳性十二指肠溃疡64例

目的探讨雷贝拉唑联用抗生素治疗幽门螺杆菌（Hp）阳性十二指肠溃疡的效果。方法将幽门螺杆菌阳性十二指肠溃疡128例患者随机分为两组,每组64例。A组口服雷贝拉唑10 mg,2次/d,连用14 d;克拉霉素500 mg,2次/d,连用7d;阿莫西林（1000 mg,2次/d,连用7 d）。B组口服奥美拉唑10 mg,2次/d,连用14 d;阿莫西林1000 mg,2次/d,连用7 d;甲硝唑400 mg,2次/d,连用7 d。在治疗过程中,两组均按研究方案记录症状缓解情况和不良反应,治疗结束后4周复查胃镜,了解Hp根除率和溃疡愈合率,并随访1年。结果疼痛缓解时间A、B两组比较差异有统计学意义（P〈0.05）,溃疡愈合率两组比较差异无统计学意义（P〉0.05）,Hp根除率两组比较差异有统计学意义（P〈0.05）,溃疡复发率两组比较差异有统计学意义（P〈0.01）,不良反应发生率雷贝拉唑为3.12%,奥美拉唑为7.81%。结论雷贝拉唑组具有疼痛缓解快、Hp根除率高、溃疡复发率低、不良反应少的优点。

Effect of rabeprazole in the treatment of duoderai ulcer with Helicobacter pylori infection in 64 eases

Objective To study the effect of antibiotic treatment of rabeprazole in the treatment of duoderal ulcer with Helicobacter pylori(Hp) infection.Methods One hundred and twenty-eight patients with active duoderal ulcer were equally divided into two groups.64 in rabeprazole group received 10 mg rabeprazole twice a day for two weeks,and 500 mg clarithromycin,1000 mg amoxicilin twice a day for one week;64 in omeprazole group received 10 mg omeprazole twice a day for two weeks,and 1000 mg amoxicilin,400 mg metronidazole twice a day for one week.During the treatment,improvement in symptoms and adverse effects were recored.Six weeks later after treatment,the eradication rate of Hp and ulcer healing rate was studied by repeated endoscopy,and randomly visiting lasted for a year.Results After the treatment,pain was relieved earlier in rabeprazole group than in omeprazole group(P<0.05);there was no significant difference in ulcer healing rate(P>0.05);and there was significant difference in eradication rate of Hp and recurrence rate of ulcer(P<0.05) between the two groups.The adverse effect rate was 3.12% in rabeprazole group and 7.81% in omeprazole group.Conclusion Compared to omeprazole,rabeprazole is quicker in relieving pain,eradication rate of Hp is higher and recurrence rate is lower and it has less adverse effects.