| Abstract: | ![]()
A model of experimental pollinosis was created in guinea pigs. The animals were kept in a chamber in which the allergen, a dialyzed aqueous extract of ragweed pollen, was dispersed by means of a coaxial nebulizer. As a result of aerosol sensitization the guinea pigs formed homocytotropic antibodies, an indication of their sensitization to the specific allergen. Sensitization of the animals to ragweed allergen was accompanied by increased sensitivity of the bronchopulmonary system and was characterized by reflex bronchospasm to a reacting inhalation or to intravenous injection of the specific allergen.Allergologic Research Laboratory, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 11, pp. 590–593, November, 1977. |
