Epithelial cysts in the central nervous system,characteristic expression of cytokeratins in an immunohistochemical study |
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| Authors: | Y. Uematsu R. R. Rojas-Corona J. F. Llena A. Hirano |
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| Affiliation: | (1) Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, Bronx, New York, USA;(2) Division of Immunopathology, Department of Pathology, Montefiore Medical Center, Bronx, New York, USA;(3) Present address: Department of Neurological Surgery, Wakayama Medical College, 640 7-27 Wakayama City, Japan |
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| Abstract: | ![]()
Summary Nineteen epithelial cysts in the central nervous system including six colloid cysts of the third ventricle, seven Rathke's cleft cysts in the sella, two enterogenous cysts in the posterior fossa, two epithelial cysts in the spinal canal and two neuroectodermal cysts in the cerebrum were examined immunohistochemically for expression of intermediate filament proteins-simple type, stratified type and skin type cytokeratins and GFAP. Colloid cysts of the third ventricle, Rathke's cleft cysts in the sella and epithelial cysts in the spinal canal expressed complex type cytokeratins while enterogenous cysts and neuro-ectodermal cysts showed only simple type cytokeratins. In addition, Rathke's cleft cysts expressed GFAP in occasional lining cells. The characteristic composition and distribution of cytokeratins in various kinds of epithelial cysts in the central nervous system are demonstrated and discussed with regard to their origins. |
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| Keywords: | Central nervous system cytokeratins epithelial cyst immunohistochemistry |
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