| 注射用头孢尼西钠与果糖注射液的配伍稳定性考察 |
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| 引用本文： | 惠慧,韩强.注射用头孢尼西钠与果糖注射液的配伍稳定性考察[J].中国药房,2011(22):2061-2062. |
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| 作者姓名： | 惠慧 韩强 |
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| 作者单位： | 徐州医学院附属医院药剂科; |
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| 摘 要： | 目的:考察注射用头孢尼西钠在室温(25±1)℃下与果糖注射液配伍的稳定性。方法:模拟临床用药浓度,将注射用头孢尼西钠1.0g加入到10mL果糖注射液中,混合均匀后,在室温(25±1)℃下考察6h内配伍液的外观和pH值变化,并采用高效液相色谱法测定头孢尼西的含量,同时考察有无新物质生成。结果:在室温(25±1)℃下,0～6h配伍液的外观、pH值、头孢尼西的含量均无明显变化。结论:注射用头孢尼西钠与果糖注射液配伍,在室温(25±1)℃下6h内配伍稳定。
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| 关 键 词： | 注射用头孢尼西钠 果糖注射液 配伍 稳定性 高效液相色谱法 |
Compatible Stability of Cefonicid Sodium for Injection with Fructose Injection |
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| HUI Hui,HANG Qiang.Compatible Stability of Cefonicid Sodium for Injection with Fructose Injection[J].China Pharmacy,2011(22):2061-2062. |
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| Authors: | HUI Hui HANG Qiang |
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| Institution: | HUI Hui,HANG Qiang(Dept. of Pharmacy,The Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China) |
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| Abstract: | OBJECTIVE： To investigate the compatible stability of Cefonicid sodium for injection with Fructose injection at room temperature （25±1）℃. METHODS： At room temperature （25±1）℃, Cefonicid sodium for injection 1.0 g was added into 10 mL Fructose injection. The appearance and pH value of mixture in 6 h were observed. The content of cefonicid was determined by HPLC, and whether new matter generated was investigated. RESULTS： At room temperature （25±1）℃, there were no changes in appearance, pH value and cefonicid sodium concentration of mixture within 0～6 h. CONCLUSION： At room temperature （25±1）℃, the compatibility of Cefonicid sodium for injection combined with Fructose injection is stable within 6h. |
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| Keywords: | Cefonicid sodium for injection Fructose injection Compatibility Stability HPLC |
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