| 头孢克肟肠溶滴丸的制备及其质量评价 |
| |
| 引用本文： | 何艳,高萌,徐红,蒋妮,田舸,田燕. 头孢克肟肠溶滴丸的制备及其质量评价[J]. 中国药房, 2011, 0(21): 1973-1975 |
| |
| 作者姓名： | 何艳 高萌 徐红 蒋妮 田舸 田燕 |
| |
| 作者单位： | 大连医科大学药学院;大连儿童医院药剂科;大连医科大学技能实验室; |
| |
| 摘 要： | 目的:制备头孢克肟肠溶滴丸并评价其质量。方法:采用滴制法制备头孢克肟滴丸,并包肠溶衣,以圆整度、重量差异及溶散时限作为评定指标,设计正交试验对包衣材料、包衣液浓度、包衣层数进行考察,优选出肠溶滴丸的最佳包衣工艺并进行验证试验,同时考察制剂的体外累积释放度。结果:最佳包衣工艺为包衣材料聚丙烯酸树脂Ⅱ号,包衣液浓度10%,包衣层数3层。验证试验表明制剂的各项指标均符合《中国药典》2010年版相关要求;45min时在碱性释放介质(pH=6.8)中体外累积释放度为(93.4±1.67)%。结论:头孢克肟肠溶滴丸的制备工艺合理,在碱性介质中释放完全,质量合格。
|
| 关 键 词： | 头孢克肟 肠溶滴丸 滴制法 制备 质量评价 体外释放度 |
Preparation and Quality Evaluation of Cefixime Enteric Coated Drop Pills |
| |
| HE Yan,GAO Meng,TIAN Ge,TIAN Yan XU Hong JIANG Ni. Preparation and Quality Evaluation of Cefixime Enteric Coated Drop Pills[J]. China Pharmacy, 2011, 0(21): 1973-1975 |
| |
| Authors: | HE Yan GAO Meng TIAN Ge TIAN Yan XU Hong JIANG Ni |
| |
| Affiliation: | HE Yan,GAO Meng,TIAN Ge,TIAN Yan(Pharmaceutical College,Dalian Medical University,Dalian 116044,China) XU Hong(Dept. of Pharmacy,Dalian Children's Hospital,Dalian 116001,China) JIANG Ni(Skill Laboratory,China) |
| |
| Abstract: | OBJECTIVE:To prepare Cefixime enteric coated drop pills and to evaluate their qualities. METHODS:The drop pills were prepared by dropping method and coated with enteric materials. Enteric coated materials,concentration and the number of layers were checked by orthogonal test using spherical degree,dissolution time and weight difference as evaluation index. And optimal coating conditions were selected. The in vitro accumulative release rate of drop pills was investigated. RESULTS:Optimal coating conditions w... |
| |
| Keywords: | Cefixime Enteric coated drop pills Dropping method Preparation Quality evaluation In vitro drug release |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
