前列地尔治疗慢性肾小球肾炎的临床观察

目的:观察前列地尔治疗慢性肾小球肾炎的临床疗效。方法:将180例慢性肾小球肾炎患者随机均分为治疗组和对照组,2组患者均采用常规治疗,治疗组在此基础上给予前列地尔10μg·d-1,12～14d为1个疗程,共2个疗程。观察并记录2组患者治疗后的24h尿蛋白定量、血肌酐(Scr)、尿红细胞计数、血尿素氮(BUN)。结果:治疗组与对照组总有效率分别为93.3%和80.0%,组间比较差异有统计学意义(P<0.05);2组治疗后24h尿蛋白定量、尿红细胞计数、Scr和BUN比较,差异有统计学意义(P<0.05)。结论:前列地尔治疗慢性肾小球肾炎临床效果显著,可降低尿蛋白的排泄,消除血尿,改善肾功能,减少终末期肾衰的发生。

Clinical Observation of Alprostadil in the Treatment of Chronic Glomerulonephritis

OBJECTIVE： To observe clinical efficacy of Alprostadil in the treatment of chronic glomerulonephritis. METHODS： 180 cases of chronic glomerulonephritis were randomly divided into treatment group and control group with 90 cases in each group. Both groups were given conventional therapy. Treatment group was additionally given alprostadil 10 μg·d-1 for 2 courses, a course lasting for 12 to 14 days. The 24 h quantitative urine protein, serum creatinine （Scr）, urine red blood cell count, and blood urea nitrogen （BUN） were investigated. RESULTS： The total effective rates of two groups were 93.3% and 80.0%, there were significant difference （P0.05）. The 24 h quantitative urine protein, Scr, urine red blood cell count, and BUN showed significance between the 2 groups （P0.05）. CONCLUSION： Alprostadil can improve the clinical symptom of chronic glomerulonephritis and reduce the proteinuria and hematuria, protect the renal function and reduce renal failure.