氯沙坦对老年高血压患者心肌纤维化改善效果的临床研究

目的 观察氯沙坦对老年高血压患者心肌纤维化的影响.方法 对44例老年高血压心肌纤维化患者口服氯沙坦(50 ～100 mg/d)治疗12～16个月,观察治疗前后患者血压和心肌纤维化改善情况.采用酶联免疫法在治疗前后各测一次血浆中Ⅲ型胶原前肽、层粘连蛋白.结果 氯沙坦治疗后血压明显下降(P＜0.01),心率无明显变化(P＞0.05),心肌纤维化指标:Ⅲ型前胶原氨基末端肽(PⅢP)、层粘连蛋白(LN)均明显降低(P＜0.05).结论 氯沙坦在有效降压的同时,部分逆转或减轻心肌纤维化,对心率无明显影响.

Clinical study of the effect of losartan in improving myocardial fibrosis of elderly hypertensive patients

Objective To investigate the effect of losartan on myocardial fibrosis in elderly patients with hypertension.Methods 44 elderly patients with hypertension and myocardial fibrosis were treated with oral losartan (50-100 mg/d) for 12-16 months.And the improved conditions of myocardial fibrosis and blood pressure were observed before and after treatment.Measured type Ⅲ ex-collagen and laminin with ELISA before and after treatment.Results After treatment,blood pressure decreased significantly (P＜0.01),heart rate did not change significantly (P＞0.05),type Ⅲ ex-collagen and laminin decreased significantly (P＜0.05).Conclusion Losartan can effectively decrease blood pressure,partly reverse or attenuate myocardial fibrosis,and has no significant effect on heart rate.