难治性颞叶癫痫危险因素的配比病例对照研究

目的 分析颞叶癫癎成为难治性癫癎的危险因素,为临床需要提供客观的指征。方法 将163例药物难治性颞叶癫癎患者与同期的非难治性颞叶癫癎患者进行1:1配比病例对照研究,应用条件Logistic回归分析方法处理数据。结果 多因素条件Logistic回归分析表明颞叶癫癎成为难治性的有统计学显著性意义的重要危险因素是:神经系统疾患(OR=3.635,95％CI:1.805-7.320)、双颞癎性放电(OR=4.289,95％CI:2.192-8.389)、海马硬化(OR=4.558,95％CI:1.890-10.992)、起病年龄早(OR=0.353,95％CI:0.144-0.867)和2年内未及时治疗(OR=0.418,95％CI:0.208-0.837)。结论 具有神经系统疾患、双颞癎性放电、海马硬化、起病年龄早和2年内未及时治疗是难治性颞叶癫癎的重要危险因素。

A matched case-control study on the risk factors of intractable temporal lobe epilepsy.

Objective To analyze the risk factors of intractable temporal lobe epilepsy and to provide the clinician with an indication of the necessity in a critical condition. Methods A 1 :1 matched case-control study was carried out in- PUMCH including 163 cases and the same number of controls. A conditional logistic regression modei was used for statistical analysis. Re-sults Multivariate conditional logistic regression analysis showed that intractable temporal lobe epilepsy was significantly associated with five risk factors including neurological disorders (OR = 3. 635, 95% CI: 1. 805 - 7. 320) , bilateral temporal epileptic dis-charges (OR = 4.289, 95%CI: 2.192-8.389), hippocampal sclerosis (OR = 4.558, 95%CI: 1.890- 10.992), early age at onset(OR = 0.353, 95%CI: 0.144-0.867) and no antiepileptic treatment within first two years (OR = 0.418, 95%CI:0.208 - 0.837) . Conclusions Neurological disorders, bilateral temporal epileptic discharges, hippocampal sclerosis, early age at onset and no antiepileptic treatment within first two years were main risk factors for intractable temporal lobe epilepsy.