| 环氧化酶-2和E-钙黏附素在脑膜瘤中的表达及临床意义 |
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| 引用本文： | 王敏,刘昆,周莉,陈冰,马广贞,马青松,解建军. 环氧化酶-2和E-钙黏附素在脑膜瘤中的表达及临床意义[J]. 中国临床实用医学, 2010, 4(11): 3-5 |
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| 作者姓名： | 王敏 刘昆 周莉 陈冰 马广贞 马青松 解建军 |
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| 作者单位： | 1. 泰山医学院附属聊城市第二人民医院病理科,252600
2. 泰山医学院附属聊城市第二人民医院神经外科 |
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| 摘 要： | 目的 探讨环氧化酶-2（Cyclooxygenase-2,COX-2）和E-钙黏附素（E-cadherin,E．cad）在人脑膜瘤中的表达及临床意义。方法应用免疫组化sP法检测60例脑膜瘤中Ki-67、COX-2、E．cad蛋白的表达情况,原位杂交方法检测COX-2mRNA、E-cadmRNA在脑膜瘤中的表达。结果Ki-67、COX-2蛋白高表达和E-cad蛋白低表达与肿瘤组织学分级、侵袭性关系密切（P〈0．05）。COX-2和E．cad表达呈负相关（P〈0．05）。结论COX-2和E-cad与脑膜瘤的病理分级、侵袭性密切相关,两者可能相互影响,共同调节脑膜瘤的侵袭性生长,联合检测COX-2和E-cad有助于判断脑膜瘤的生物学行为及预后。
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| 关 键 词： | 脑膜瘤 环氧化酶-2 E-钙黏附素 免疫组织化学 原位杂交 |
Clinical significance and expression of cyclooxygenase-2 and E-cadherin in meningioma |
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| Affiliation: | WANG Min, LIU Kun, ZHOU Li,et al.( Department of Pathology. The Second People＇s Hospital of Liaocheng City, Affiliated to Taishan Medical College, Shandong, Liaocheng, 252600, China) |
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| Abstract: | Objective To investigate the expression of cyclooxygenase-2 (COX-2) and E-cadherin( Ecad) in meningioma and the clinical significance. Methods The expressions of Ki-67, COX-2 and E-cad were detected in 60 cases of meningioma by immunohistochemistry method, and the expressions of COX-2 mRNA、EcadmRNA were examined by in situ hybridization. Results There was significant correlation between over-expression of Ki-67、 COX-2 and decreased expression of E-cad with pathologic grade and invasion ( P ＜ 0. 05 ).There was negative correlation between the expression of COX-2 and E-cad ( P ＜ 0. 05 ). Conclusion Expressions of COX-2 and E-cad were significant correlated to pathologic grade and invasion. They may exert mutual effect and co-regulate the invasive growth of meningiomas. Combined detection of COX-2 and E-cad may help to predict the prognosis of patients. |
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| Keywords: | Meningioma Cyclooxygenase-2 E-cadherin Immunohistochemistry In situ hybridization |
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