表阿霉素聚氰基丙烯酸正丁酯磁性纳米粒的制备与表征

目的 制备表阿霉素聚氰基丙烯酸正丁酯磁性纳米粒(EPI-PBCA-MNPs)并进行表征.方法 以化学共沉淀法制得粒径(15.2±4.6)am的Fe3O4纳米磁流体,采用微乳液反相界面聚合法制得EPI-PBCA-MNPs,反应条件:pH=2.0,搅拌速度2000 r/min,然后对其进行相关表征.结果 EPI-PBCA-MNPS粒径为(152.0 ±28.5)nm,分布均匀,胶体溶液长期稳定,平均包封率为(81.30 ±15.20)%,平均载药量为(14.65±2.05)%,饱和磁化强度为:0.35 KA/m.结论 制备的EPI-PBCA-MNPs粒径合适,分布均匀,其主要指标符合肝癌靶向治疗的要求.

Abstract：

Objective To prepare and characterize epirubicin polybutylcyanoacrylate magnetic nanoparticles ( EPI-PBCA-MNPs) for the purpose of offering a new dosage form of high-performance for targeted therapy of hepatoma. Methods Nanosized Fe3 O4 magnetic fluids with the mean particle diameter of (15. 2 ±4. 6) nm were prepared by chemical coprecipitation method. Subsequently, EPI-PBCA-MNPs was prepared by a reversed-phase micro-emulsion polymerization method, of which reactive condition was pH = 2. 0 and agitating velocity = 2000 r/min, and was correlatively characterized. Results EPI-PBCA-MNPs were uniformly and stably distributed in the colloid solution with the mean particle diameter of (152.0 ±28. 5) nm. The mean envelopment rate, drug-loading, saturated magnetization intensity is (81. 30 ±15. 20) % ,(14. 65 ± 2.05) % ,0. 35 KA/m, respectively. Conclusion In this experiment, EPI-PBCA-MNPs is uniformly distributed with satisfactory particle diameter,of which main indexes meet the demand of targeted therapy for hepatoma, offering a new dosage form with applicable potential for anticancer drugs exploration.

Preparation and characterization of epirubicin polybutylcyanoacrylate magnetic nanoparticles

Objective To prepare and characterize epirubicin polybutylcyanoacrylate magnetic nanoparticles ( EPI-PBCA-MNPs) for the purpose of offering a new dosage form of high-performance for targeted therapy of hepatoma. Methods Nanosized Fe3 O4 magnetic fluids with the mean particle diameter of (15. 2 ±4. 6) nm were prepared by chemical coprecipitation method. Subsequently, EPI-PBCA-MNPs was prepared by a reversed-phase micro-emulsion polymerization method, of which reactive condition was pH = 2. 0 and agitating velocity = 2000 r/min, and was correlatively characterized. Results EPI-PBCA-MNPs were uniformly and stably distributed in the colloid solution with the mean particle diameter of (152.0 ±28. 5) nm. The mean envelopment rate, drug-loading, saturated magnetization intensity is (81. 30 ±15. 20) % ,(14. 65 ± 2.05) % ,0. 35 KA/m, respectively. Conclusion In this experiment, EPI-PBCA-MNPs is uniformly distributed with satisfactory particle diameter,of which main indexes meet the demand of targeted therapy for hepatoma, offering a new dosage form with applicable potential for anticancer drugs exploration.