| 骨桥蛋白在卵巢癌组织中的表达及意义 |
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| 引用本文： | 马哲,张虹. 骨桥蛋白在卵巢癌组织中的表达及意义[J]. 现代诊断与治疗, 2011, 22(3): 131-133 |
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| 作者姓名： | 马哲 张虹 |
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| 作者单位： | 1. 天津医科大学,天津,300070;天津市中心妇产科医院,天津,300100
2. 天津市中心妇产科医院,天津,300100 |
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| 摘 要： | 目的探讨骨桥蛋白(OPN)在卵巢癌组织中的表达及临床意义。方法采用免疫组化法检测35例上皮性卵巢癌组织、17例交界性卵巢肿瘤、15例卵巢良性肿瘤组织及6例正常卵巢组织标本中OPN的表达,分析其与临床病理特征的关系及相关性。结果 OPN在上皮性卵巢癌、交界性卵巢肿瘤、卵巢良性肿瘤及正常卵巢组织中阳性表达率分别为69%、65%、26%及0%(P<0.05)。OPN在卵巢浆液性囊腺癌及黏液性囊腺癌组织表达不具有统计学差异(P>0.05)。结论OPN在卵巢癌组织中显著高表达;其表达和术前血CA125水平相关,是卵巢癌早期诊断、病情监测及评价预后的生物标志物之一。
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| 关 键 词： | 骨桥蛋白 上皮性卵巢肿瘤 免疫组化 |
Expression of Osteopontin in Epithelial Ovarian Cancer and Its Significance |
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| MA Zhe,ZHANG Hong. Expression of Osteopontin in Epithelial Ovarian Cancer and Its Significance[J]. Modern Diagnosis & Treatment, 2011, 22(3): 131-133 |
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| Authors: | MA Zhe ZHANG Hong |
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| Affiliation: | MA Zhe1,2,ZHANG Hong2(1.Tianjin Medical University,Tianjin 300070,China,2.Tianjin City Central Hospital of Obstetrics and Gynecology,Tianjin 300100,China) |
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| Abstract: | Objective To investigate the expression of osteopontin(OPN) in epithelial ovarian cancer and its significance.Method Expressions of OPN were detected by immunohistochemistry method in 35 patients with epithelial ovarian cancer,17 patients with borderline ovarian tumor,15 patients with ovarian benign tumor and 6 samples of normal ovarian tissues.The correlation between the expression of OPN and clinicopathological features was analyzed.Results The expression of OPN in ovarian cancer(69%) was higher than thos... |
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| Keywords: | Osteopontin Epithelial ovarian cancer Immunohistochemistry |
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