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ANTILEUKEMIC EFFECT OF LOW-DOSE HARRINGTONINE |
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| Authors: | S S Chen P Wang J Y Fu L L Chen F S Zhao F X Shan |
| Abstract: | The effect of harringtonine (HA) in various concentrations on HL-60 was evaluated. 0.10 microgram/ml HA showed a strong cell killing effect, and 0.025 microgram/ml HA a weak differentiation induction accompanied by cell growth retardation. Differentiation induction did not occur in 5 other human leukemic cell lines. We consider that antileukemic effect of HA is cytotoxicity, not differentiation induction. |
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