常州农村地区高血压相关危险因素的巢式病例对照研究

目的:以大样本人群队列为基础,探讨常州农村地区人群高血压发病的相关危险因素,为高血压的早期防治提供参考依据?方法:采用巢式病例对照研究,选取常州市武进区慢性病队列中经两次随访新发高血压患者作为病例组(3 400例),按照性别?年龄进行频数匹配(1∶1),随机选取3 400例基线和两次随访均未患高血压的正常样本为对照,高血压的相关影响因素分析采用单因素和多因素Logistic回归分析?结果:单因素Logistic回归结果表明,饮酒?体重指数?总胆固醇和甘油三酯与高血压的发病相关;进一步多因素Logistic回归结果显示,饮酒?超重?肥胖?总胆固醇和甘油三酯异常可增加高血压的发病风险,而低体重为高血压的保护因素?结论:饮酒?超重或肥胖?血脂异常可能是影响常州农村地区高血压发病的危险因素,应当针对重点人群进行早期干预,降低高血压发病风险?

A nested case-control study on risk factors of hypertension in Changzhou rural areas

Objective:We sought to use large sample size cohort to investigate the related risk factors of hypertension in rural communities of Changzhou,the results would help take intervention measures for onset hypertension. Methods: In this nested case-control study,3 400 new cases with hypertension were included,and 3 400 non-hypertension controls were randomly matched by sex and age. The related risk factors were detected by single and multi-variate Logistic regression. Results: Single-variate Logistic regression showed that drink, body mass index (BMI), total cholesterol (TC) and triglyceride(TG) were associated with hypertension; further multi-variate logistic regression showed that drink,overweight,obesity, TC and TG increased the risk of hypertension and low weight reduced the risk. Conclusion: Hypertension was related to drink,overweight, obesity and lipoprotein level in rural communities of Changzhou. Taking integrated intervention measures of high risk groups is an important way to reduce the risk of hypertension.