| 流感病毒神经氨酸酶抑制剂构效关系研究 |
| |
| 引用本文： | 胡静,王尔华. 流感病毒神经氨酸酶抑制剂构效关系研究[J]. 药学进展, 2004, 28(5): 204-208 |
| |
| 作者姓名： | 胡静 王尔华 |
| |
| 作者单位： | 中国药科大学医药化工研究所,江苏,南京,210009 |
| |
| 摘 要： | 神经氨酸酶在流感病毒的感染和传播过程中起着重要作用。针对酶活性位点进行基于结构的合理药物设计，开发各类流感病毒神经氨酸酶抑制剂，业已成为药物研究的热点之一。根据化学结构的不同，综述各类神经氨酸酶抑制剂的作用机制及构效关系。
|
| 关 键 词： | 流感病毒 神经氨酸酶抑制剂 作用机制 构效关系 药物开发 |
| 文章编号： | 1001-5094(2004)05-0204-05 |
| 修稿时间： | 2004-01-27 |
Studies on Structure-activity Relationship of Influenza Neuraminidase Inhibitors |
| |
| HU Jing,WANG Er-hua. Studies on Structure-activity Relationship of Influenza Neuraminidase Inhibitors[J]. Progress in Pharmaceutical Sciences, 2004, 28(5): 204-208 |
| |
| Authors: | HU Jing WANG Er-hua |
| |
| Affiliation: | HU Jing,WANG Er-hua* |
| |
| Abstract: | Neuraminidase plays an important role in the pathogenicity of influenza infections. Structure-based rational drug design targeted for the active sites of influenza neuraminidase, resulting in development of varied kinds of influenza neuraminidase inhibitors, has been a hotspot of drug resarch. The acting mechanism and structure-activity relationship of each kind of influenza neuraminidase inhibitors with dissimilar structures were reviewed. |
| |
| Keywords: | Influenza neuraminidase inhibitor Active site Acting mechanism Structure-activity relationship |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
