Extracorporeal photopheresis as second‐line treatment therapy in life‐threatening primary graft dysfunction following lung transplantation |
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| Authors: | Cécile A Robinson Ilhan Inci Mirjam Naegeli Christian Murer Macé M Schuurmans Mirjana Urosevic‐Maiwald Reto Schüpbach Walter Weder Christian Benden |
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| Affiliation: | 1. Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland;2. Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland;3. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland;4. Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland |
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| Abstract: | ECP is an established “second‐line” treatment for CLAD/BOS. Recently, ECP was used for the first time in an adolescent CF patient as a “second‐line” treatment therapy in life‐threatening primary graft dysfunction following lung transplantation who deteriorated despite extensive treatment including ECMO and ATG. Within 10 days after initiation of ECP twice weekly, allograft function and clinical status improved significantly and the patient was weaned from mechanical ventilation support. ECP has been continued every 2 weeks since. Two hundred days after lung transplantation, the patient has an acceptable allograft function (FEV1 67%) and no signs of allograft rejection. We advocate that use of ECP and its immunomodulatory effects should be evaluated in the early period following lung transplantation. |
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| Keywords: | primary graft dysfunction extracorporeal photopheresis lung transplantation |
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