透镜对豚鼠眼屈光不正和眼轴的作用

观察凹透镜和凸透镜对豚鼠眼球生长和屈光变化的影响，建立透镜诱导型屈光不正动物模型。方法：3～4周龄有色豚鼠47只，随机分成7组，右眼分别戴不同度数的凸或凹透镜，其左眼作为对照眼，戴镜前和戴镜后第11天分别测量其眼轴长度、屈光度，观察其变化。结果：戴镜后第11天与戴镜前相比，戴+4.00?D、+8.00?D组的豚鼠眼分别增加了+1.46?D与+1.58?D的相对远视（P＜0.05）；戴-4.00?D、-8.00?D、-15.00?D组的豚鼠分别增加了-2.92?D、-3.17?D、-3.10?D的相对近视（P＜0.01）；而戴0.00?D、-2.00?D组的豚鼠的屈光度差异无统计学意义（P＞0.05）。7组豚鼠的眼轴长度在实验眼和对照眼之间差异无统计学意义（P＞0.05）。结论：豚鼠眼球生长发育受透镜影响，可被用来建立一种简单经济的屈光不正动物模型。

Effect of lens on refractive error and axial length of guinea pig

Objective: To observe the effect of concave and convex on growing and the refractive developing of guinea pig eyes and to establish lens-induced animal model of myopia or hyperopia.Methods: Forty-seven 3-4-week guinea pigs were randomly divided into 7 groups,who wore different degrees concave or convex spherical lenses on their right eyes and none on the left eyes as control.The axial length and refraction were measured before and 11 days after wearing lenses.Results: On the 11th day after wearing lenses,the lens-wearing eyes of group 4.00D and 8.00D became hyperopic(on average 1.46D,and 1.58D,respectively)(P<0.05),whereas of group-4.00D,-8.00D,and-15.00D became myopic(on average-2.92D,-3.17D,and-3.10D,respectively)(P<0.01),and of group 0.00D and-2.00D had not significantly changed(P>0.05).There was no significantly different in axial length among all 7 groups(P>0.05).Conclusion: Guinea pig eyes can be influenced by lens,suggesting it can be used as a simple economic mammal model in myopia or hyperopia study.