术中射频治疗在剖胸探查晚期非小细胞肺癌治疗中的作用和意义

目的探讨术中射频治疗在剖胸探查晚期非小细胞肺癌治疗中的作用和意义。方法2002年1月至2004年12月23例剖胸探查无法手术切除的晚期非小细胞肺癌患者行术中射频治疗为治疗组(n=23,A组),同期无法手术切除的晚期非小细胞肺癌30例给予化疗为对照组(n=30,B组),观察术后疗效、疼痛缓解程度、ECOG评分、术后生活质量。结果A组的治疗、疼痛缓解程度、ECOG评分及治疗后生活质量的好转率分别为65.22%、65.22%、60.86%、65.21%;B组为36.67%,33.33%,33.33%,30.00%。射频治疗组优于化疗组。(P<0.05)结论术中射频治疗可有效地提高不可切除的晚期非小细胞肺癌的术后疗效和生存质量,对于晚期非小细胞肺癌提供了新的治疗途径。

Clinical effect and value on radiofrequency ablation for the treatment of advanced non-small cell lung cancer during exploratory thoracotomy

Objective To explore the significance and clinical effect on intraoperative adiofrequency ablation for treating advanced non-small cell lung cancer.Methods From January 2002 to December 2004,53 cases with unresectable advanced non-small cell lung cancer were divided into two groups.Among them,23 cases received intraoperative radio-frequency ablation were as therapeutic group(Group A)and other 30 cases received chemotherapy were as control group(Group B).The curative effectk,painful remission rate,ECOG score and quality of life were observed and compared.Results The efficacy rate of treatment result,pain remission,ECOG score,and the life of quality in group A were 65.22%?65.22%?60.86%?60.86%,vs 36.67%,33.33%,33.33%,30.00% in group B respectively.The efficacy rate in group A higher than that in group B.(P<0.05).Conclusion Intraoperative radio-frequency oblation can improve postoperative curative effect and quality of life for unresectable advanced non-small cell lung cancer and it would provide a new therapeutic approach.