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| PK/PD参数与抗菌药物的优化用药 | |
| 引用本文： | 熊旭东. PK/PD参数与抗菌药物的优化用药[J]. 抗感染药学, 2012, 9(1): 11-13 |
| 作者姓名： | 熊旭东 |
| 作者单位： | 上海中医药大学附属曙光医院,上海,200021 |
| 摘 要： | 反映时间依赖性抗菌药物的PK/PD参数为t>MIC,反映浓度依赖性抗菌药物的PK/PD参数为cmax/MIC或AUC/MIC。时间依赖性与浓度依赖性抗菌药物都与抗菌药物后效应(PAE)和半衰期(t1/2)密切相关。运用PK/PD参数优化抗菌药物的合理用药,叙述了时间依赖性和浓度依赖性抗菌药物及其运用PK/PD参数优化用药的注意点。 |
| 关 键 词： | PK/PD参数 抗菌药物 优化用药 |
PK/PD Parameters and Optimization of Anti-microbial Drug |
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| XIONG Xu-dong. PK/PD Parameters and Optimization of Anti-microbial Drug[J]. Anti-infection Pharmacy, 2012, 9(1): 11-13 | |
| Authors: | XIONG Xu-dong |
| Affiliation: | XIONG Xu-dong* Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 200021, China |
| Abstract: | PK/PD parameter reflecting the time-dependent antimicrobial is t>MIC, and PK/PD parameters reflecting the concentration-dependent antimicrobial are cmax/MIC or AUC/MIC.The time-dependent and the concentration-dependent antimicrobial drugs are closely related with the PAE and half life period(t1/2).The optimized medication and the matters needing attention in time-dependence and the concentration-dependence antimicrobial by PK/PD parameters were described |
| Keywords: | PK/PD parameters anti-microbial drug optimal treatment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |